Adrance-M Tablet 5mg / 850mg

About Adrance-M Tablet 5mg / 850mg

Adrance-M Tablet 5mg / 850mg Uses

• Controls high blood sugar in adults with type 2 diabetes
• Used alongside diet and exercise when metformin alone is not enough
• Helps reduce the risk of major cardiovascular events in patients with type 2 diabetes and heart disease
• Supports long term blood sugar management as part of a combination regimen

Adrance-M Tablet 5mg / 850mg Benefits

• Combines two different mechanisms of action for better blood sugar control in one tablet
• Empagliflozin also supports modest weight loss and slightly lowers blood pressure
• May lower the risk of heart failure hospitalization in patients with type 2 diabetes
• Simplifies treatment by reducing the number of tablets needed each day

What Experts Say

Adrance-M Tablet 5mg / 850mg combines empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, with metformin, a biguanide that has been a first line diabetes medicine for decades. Doctors favor this combination because the two drugs lower blood sugar through completely different pathways, which often gives better control than either medicine alone at a similar dose.

Pakistan carries one of the highest burdens of type 2 diabetes in the world, and physicians frequently move patients to combination therapy earlier than in many other countries once metformin alone stops keeping blood sugar in target range. Empagliflozin's added benefit of reducing cardiovascular and kidney strain makes this combination especially useful for patients who also have high blood pressure or early kidney changes.

Doctors typically check kidney function before starting this tablet and periodically afterward, since both drugs depend on adequate kidney function to work safely. Patients are also counselled about staying hydrated and watching for genital infections, a known class effect of SGLT2 inhibitors that responds well to early treatment.

Drug Class

• SGLT2 inhibitor + biguanide combination

Adrance-M Tablet 5mg / 850mg formula

• Empagliflozin + Metformin

Available forms

• Tablet

How to use Adrance-M Tablet 5mg / 850mg?

• Take Adrance-M Tablet 5mg / 850mg exactly as prescribed by your doctor
• Swallow the tablet whole with a meal to reduce stomach upset
• Take it at the same time each day for consistent blood sugar control
• Drink enough water through the day while on this medicine
• Do not double the dose if you miss one, just take the next dose as scheduled

Drug Interactions

• Insulin And Sulfonylureas: Combining with these raises the risk of low blood sugar, dose adjustment may be needed
• Diuretics: Increase the risk of dehydration and low blood pressure when combined with empagliflozin
• Iodinated Contrast Dye: Metformin should be temporarily stopped around the time of a contrast imaging test due to acute kidney injury risk
• Alcohol: Excess alcohol raises the risk of lactic acidosis with metformin

Risks and warnings

• Lactic Acidosis: A rare but serious risk with metformin, more likely in patients with kidney or liver problems
• Ketoacidosis: Empagliflozin can rarely cause diabetic ketoacidosis even when blood sugar is not very high
• Genital Infections: Increases the risk of yeast infections and urinary tract infections
• Dehydration And Low Blood Pressure: Can occur, especially in elderly patients or those on diuretics
• Kidney Function: Not recommended in patients with significantly reduced kidney function
• Surgery Or Contrast Dye Procedures: Should be paused before major surgery or an imaging test that uses iodinated contrast dye

Adrance-M Tablet 5mg / 850mg Side Effects

• Nausea
• Diarrhea
• Stomach upset
• Increased urination
• Genital yeast infections
• Urinary tract infections
• Thirst
• Low blood sugar when combined with insulin or sulfonylureas
• Vitamin B12 deficiency with long term use
• Metallic taste in the mouth

Storage Conditions

• Store below 30°C in a cool, dry place away from moisture
• Keep the tablets in their original packaging until use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack