Afdol Tablet 10 mg

About Afdol Tablet 10 mg

Afdol Tablet 10 mg Uses

• Treats moderate to severe memory and thinking problems in Alzheimer's disease.
• Used alone or together with other Alzheimer's medicines like donepezil.
• Helps patients manage daily activities for longer during advanced dementia.

Afdol Tablet 10 mg Benefits

• Can slow the worsening of memory, confusion and daily function in Alzheimer's disease.
• Works differently from other dementia drugs, so it is often combined with them.
• Gradual dose increase helps the body adjust with fewer side effects.

What Experts Say

Memantine works by blocking NMDA receptors that respond to glutamate, a brain chemical that becomes overactive in Alzheimer's disease. Excess glutamate activity is thought to damage nerve cells over time, so partially blocking these receptors may help protect remaining brain function.

Unlike cholinesterase inhibitors used in milder Alzheimer's disease, memantine targets a completely different pathway, which is why specialists often prescribe both drug classes together in moderate to severe stages. This combination approach aims to slow decline from two separate angles.

Doctors increase the dose gradually over several weeks to reduce dizziness and confusion during the adjustment period. Because the kidneys clear this drug, dosing is adjusted downward in patients with reduced kidney function, and urine pH changes from certain other medicines can also affect how quickly it leaves the body.

Drug Class

• NMDA Receptor Antagonist
• Anti Dementia Agent

Afdol Tablet 10 mg formula

• Memantine Hydrochloride

Available forms

• Tablet

How to use Afdol Tablet 10 mg?

• Take Afdol Tablet exactly as prescribed, usually starting with a low dose.
• Your doctor will increase the dose gradually over several weeks.
• Swallow the tablet with water, with or without food.
• Take it at the same times each day for a steady effect.

Drug Interactions

• Amantadine: Another NMDA blocker, combined use raises the risk of side effects.
• Dextromethorphan: Found in cough syrups, can interact with memantine's mechanism.
• Sodium bicarbonate: Alkalinizes urine and can raise memantine levels in the blood.
• Carbonic anhydrase inhibitors: Used for glaucoma, can also reduce drug clearance.
• Ketamine: Combined NMDA blockade may increase central nervous system side effects.

Risks and warnings

• Confusion or dizziness: More common when the dose is increased too quickly.
• Kidney impairment: Requires a lower maximum dose since the drug is cleared by the kidneys.
• Seizure history: Use with caution in patients with a history of seizures.
• Urinary tract conditions: Changes in urine pH can raise or lower drug levels in the blood.
• Pregnancy: Use only if clearly needed, since safety in pregnancy is not fully established.

Afdol Tablet 10 mg Side Effects

• Dizziness
• Headache
• Confusion
• Constipation
• Drowsiness
• High blood pressure
• Vomiting
• Unusual tiredness

Storage Conditions

• Store between 15°C and 30°C in a cool, dry place.
• Keep the tablets in their original blister pack.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.