Aldactone Tablet 100mg

About Aldactone Tablet 100mg

Uses

• Treats fluid retention (edema) linked to heart failure, liver cirrhosis, or kidney disease
• Manages high blood pressure, including resistant hypertension
• Used as add on therapy in heart failure with reduced ejection fraction
• Treats primary hyperaldosteronism (Conn syndrome)
• Helps control ascites in patients with liver disease
• Sometimes used off label for hormonal acne and excess hair growth in women

Benefits

• Reduces swelling in the legs, abdomen, and lungs caused by fluid buildup
• Lowers blood pressure while helping the body retain potassium, unlike other diuretics
• Improves survival and reduces hospital readmission in eligible heart failure patients
• Provides a gentler, longer acting diuretic effect suited for long term use

What Experts Say

Aldosterone antagonism gives spironolactone a distinct advantage in patients with resistant hypertension and heart failure with reduced ejection fraction, since it blocks the neurohormonal pathway that drives fluid retention and cardiac remodeling rather than simply forcing fluid loss through the kidneys.

Physicians weigh the diuretic benefit against a real hyperkalemia risk, especially in patients with reduced kidney function or those already taking an ACE inhibitor, ARB, or potassium supplement, so baseline and periodic serum potassium and creatinine checks are considered standard monitoring practice with this drug class.

The onset of the diuretic effect is gradual, often taking two to three days to become fully apparent, which is why dose adjustments are usually spaced out rather than made daily. Gynecomastia and menstrual irregularities are also more common with spironolactone than with other diuretics, since the drug has weaker anti androgen and progestational activity in addition to its main effect.

Drug Class

• Potassium sparing diuretic
• Aldosterone receptor antagonist

Aldactone Tablet 100mg formula

• Spironolactone 100mg

Available forms

• Tablet

How to use Aldactone Tablet 100mg?

• Take Aldactone Tablet 100mg by mouth, usually once daily or as split doses, exactly as prescribed by the doctor
• Take with food to reduce stomach upset and improve absorption
• Do not crush, chew, or split the tablet unless advised
• Swallow with a full glass of water
• Take at the same time each day to maintain a steady effect
• Do not stop the medicine suddenly without consulting the doctor, especially in heart failure
• Follow up for blood tests as advised to monitor potassium and kidney function

Drug Interactions

• ACE inhibitors such as lisinopril or enalapril, raising hyperkalemia risk
• Angiotensin receptor blockers (ARBs) such as losartan or valsartan
• Potassium supplements or potassium containing salt substitutes
• NSAIDs like ibuprofen or diclofenac, which can reduce the diuretic effect and increase kidney strain
• Other potassium sparing diuretics or aldosterone antagonists
• Lithium, since spironolactone can raise lithium blood levels
• Digoxin, as spironolactone can alter its blood levels
• Heparin, which may add to the hyperkalemia risk
• Trimethoprim, including in combination antibiotics, which can further raise potassium

Risks and warnings

• Can cause dangerously high potassium levels (hyperkalemia), particularly in patients with kidney disease
• Not recommended in patients with severe kidney failure, Addison disease, or high baseline potassium
• Should be used cautiously in the elderly and in patients with diabetes
• Requires periodic blood tests to check potassium and kidney function during long term use
• Not advised during pregnancy unless clearly needed, and caution is required while breastfeeding
• Avoid excessive sun exposure since the drug can increase skin sensitivity to sunlight
• Use with caution in patients with liver disease due to a risk of electrolyte imbalance

Aldactone Tablet 100mg Side Effects

• Increased urination and thirst
• Dizziness or lightheadedness
• Headache
• Nausea, vomiting, or stomach cramps
• Diarrhea
• Dry mouth
• Fatigue or muscle weakness
• Gynecomastia (breast enlargement or tenderness in men)
• Menstrual irregularities in women
• Skin rash
• Hyperkalemia (high potassium levels)
• Confusion in severe electrolyte imbalance

Storage Conditions

• Store Aldactone Tablet 100mg at room temperature, between 15 and 30 degrees Celsius
• Keep in a dry place away from direct sunlight and moisture
• Keep the strip in its original packaging until ready to use
• Keep out of reach of children
• Do not store in the bathroom or near the kitchen sink
• Discard any expired or unused tablets safely