Ampiclox Capsule 500mg

About Ampiclox Capsule 500mg

Uses

• Bacterial respiratory tract infections such as bronchitis and pneumonia
• Skin and soft tissue infections
• Urinary tract infections
• Ear, nose and throat infections
• Wound infections after surgery or injury

Benefits

• Combines two penicillins for broader antibacterial coverage
• Cloxacillin component protects against penicillinase producing staphylococcus
• Oral capsule allows convenient outpatient treatment
• Well established antibiotic with decades of clinical use in Pakistan

What Experts Say

Ampiclox Capsule pairs ampicillin with cloxacillin, a combination designed to close the resistance gap left by penicillinase producing staphylococcus. Ampicillin alone breaks down quickly when exposed to this enzyme, so cloxacillin protects the combination and extends its usefulness against mixed infections.

Clinicians typically prescribe 500mg every 6 hours for adults with respiratory tract infections, skin and soft tissue infections, and urinary tract infections where staphylococcus involvement is suspected. Dosing on an empty stomach improves ampicillin absorption and keeps drug levels steady across the day.

Antibiotic resistance patterns across Pakistan make combination penicillins like this one clinically relevant for empirical therapy before culture results return. Physicians still weigh renal function and prior penicillin allergy carefully, since cross reactivity with other beta lactam antibiotics remains a genuine safety concern.

Drug Class

• Penicillin class antibiotic combination
• Beta lactam antibacterial

Ampiclox Capsule 500mg formula

• Ampicillin + Cloxacillin

Available forms

• Capsule

How to use Ampiclox Capsule 500mg?

• Take one capsule every 6 hours, or as prescribed by your doctor
• Take on an empty stomach, about an hour before or two hours after a meal
• Swallow the capsule whole with a full glass of water
• Space doses evenly across the day to keep drug levels steady
• Complete the full prescribed course even if symptoms improve early
• Do not double a dose if one is missed, take the next dose as scheduled

Drug Interactions

• Oral contraceptives: May reduce the reliability of hormonal contraception
• Allopurinol: Combined use raises the risk of skin rash
• Methotrexate: Ampicillin can raise methotrexate levels and increase toxicity risk
• Probenecid: Slows elimination of ampicillin and raises blood levels
• Warfarin and other anticoagulants: May alter bleeding risk, monitor closely if used together
• Other antibiotics: Bacteriostatic antibiotics such as tetracyclines may reduce effectiveness if given together

Risks and warnings

• Penicillin allergy: Do not take if you have a known allergy to penicillin or cephalosporin antibiotics
• Severe allergic reaction: Seek emergency care immediately for swelling of the face or throat, breathing difficulty or widespread rash
• Kidney disease: Use with caution and dose adjustment in patients with reduced kidney function
• Pregnancy and breastfeeding: Use only if a doctor confirms the benefit outweighs the risk
• Persistent diarrhea: Bloody or severe diarrhea during or after treatment requires urgent medical review
• Glandular fever: Ampicillin type antibiotics can trigger a widespread rash in patients with infectious mononucleosis

Ampiclox Capsule 500mg Side Effects

• Nausea and vomiting
• Diarrhea or loose stools
• Abdominal discomfort or bloating
• Skin rash or mild itching
• Headache
• Vaginal yeast infection or oral thrush
• Severe allergic reaction with swelling and breathing difficulty
• Severe or bloody diarrhea suggestive of colitis
• Unusual bleeding or bruising

Storage Conditions

• Store below 25°C in a cool, dry place away from direct sunlight and moisture
• Keep capsules in their original blister strip until ready to use
• Avoid storing in a bathroom cabinet where humidity is high
• Keep the strip in its outer carton to protect from light
• Keep out of reach of children