Amplus Injection IV/IM 500mg

About Amplus Injection IV/IM 500mg

Amplus Injection IV/IM 500mg Uses

• Treats respiratory tract infections like pneumonia and bronchitis
• Treats skin and soft tissue infections caused by susceptible bacteria
• Treats urinary tract infections in adults and children
• Treats septicaemia and other severe systemic bacterial infections
• Used before and after surgery to prevent bacterial infection

Amplus Injection IV/IM 500mg Benefits

• Combines two penicillins for wider bacterial coverage in one injection
• Cloxacillin protects Ampicillin from being broken down by resistant bacteria
• Works quickly since it is given directly into the vein or muscle
• Suitable for patients who cannot take oral antibiotics

Amplus Injection IV/IM 500mg Dosage

• Given only by a doctor or trained healthcare worker in hospital or clinic
• Usual adult dose is 500mg to 1gm every 6 hours by IV or IM route
• Dose in children is calculated according to body weight
• Course length depends on the type and severity of infection

What Experts Say

Ampicillin is a broad spectrum aminopenicillin that stops bacteria from building their protective cell wall. Cloxacillin resists the beta lactamase enzyme many staphylococci use to destroy plain penicillins, so combining both extends coverage to bacteria that would survive Ampicillin alone.

Doctors across Pakistan prescribe this combination often because bacterial infections needing hospital level care remain common, and beta lactamase producing staphylococcal strains are frequently seen in local culture reports. Giving the antibiotic by injection ensures full absorption in patients who are vomiting, unconscious or too unwell to swallow tablets reliably.

Regular monitoring for allergic reactions is essential since penicillin allergy is among the most common drug allergies encountered in clinical practice. Kidney function and the injection site are checked routinely, and the full course is completed even if symptoms improve early to prevent resistant bacteria from developing.

Amplus Injection IV/IM 500mg formula

• Ampicillin 250mg + Cloxacillin 250mg

Available forms

• Injection

How to use Amplus Injection IV/IM 500mg?

• Administered only by a doctor or qualified healthcare professional
• Given as a slow intravenous injection or deep intramuscular injection
• Reconstituted with sterile water or saline before use
• Dose and frequency are set according to the type of infection being treated
• Complete the full prescribed course even after symptoms improve

Drug Interactions

• Allopurinol: Increases the risk of skin rash when taken with Ampicillin
• Oral Contraceptives: May reduce the effectiveness of birth control pills
• Methotrexate: Ampicillin can raise Methotrexate levels and increase toxicity risk
• Probenecid: Increases Ampicillin blood levels by slowing its removal from the body

Risks and warnings

• Allergic Reaction: Can cause rash, swelling or breathing difficulty in patients allergic to penicillin
• Kidney Impairment: Dose adjustment needed in patients with reduced kidney function
• Pregnancy And Breastfeeding: Use only if the doctor considers it clearly necessary
• Superinfection: Prolonged use may lead to overgrowth of resistant bacteria or fungal infection

Amplus Injection IV/IM 500mg Side Effects

• Pain or redness at the injection site
• Nausea, vomiting or diarrhea
• Skin rash or itching
• Headache
• Severe allergic reaction with swelling of the face or throat
• Severe diarrhea caused by Clostridioides difficile infection

Storage Conditions

• Store the unopened vial below 25°C in a cool dry place
• Keep away from direct sunlight and moisture
• Use the reconstituted solution within the time stated by the pharmacist, usually a few hours
• Keep out of reach of children
• Do not use if the powder has changed color or the vial is damaged