Angiwell XR Tablet 500mg

About Angiwell XR Tablet 500mg

Angiwell XR Tablet Uses

• Long-term management of chronic stable angina
• Add-on therapy when other anti-anginal drugs are not enough
• Used alongside beta-blockers, nitrates, or calcium channel blockers

Angiwell XR Tablet Benefits

• Reduces the frequency of angina episodes
• Improves exercise tolerance in chronic angina
• Works without significantly lowering heart rate or blood pressure
• Complements other standard anti-anginal treatments

What Experts Say

Ranolazine works differently from most anti-anginal drugs by targeting the late sodium current in heart muscle cells, which helps reduce calcium overload and improve the heart's oxygen efficiency during physical exertion. Unlike beta-blockers, nitrates, or calcium channel blockers, it does not significantly lower heart rate or blood pressure.

Because of this, cardiologists often add ranolazine to a patient's regimen when beta-blockers, nitrates, or calcium channel blockers alone are not enough to control angina symptoms. It is also commonly considered for patients with diabetes, since research suggests a modest favourable effect on blood sugar control alongside its anti-anginal benefit.

Since ranolazine can prolong the heart's QT interval, doctors typically review a patient's other medicines and any history of irregular heartbeat before starting treatment. Dose adjustments are usually needed in kidney or liver impairment, and combining it with strong CYP3A4 inhibitors such as certain antifungals is generally avoided because it can raise ranolazine levels in the blood.

Drug Class

• Anti-Anginal Agent (Late Sodium Current Inhibitor)

Angiwell XR Tablet 500mg formula

• Ranolazine

Available forms

• Tablet (Extended-Release)

How to use Angiwell XR Tablet 500mg?

• Swallow the tablet whole with water.
• Do not crush, break, or chew the extended-release tablet.
• Take with or without food, usually twice daily.
• Take at the same times each day for consistent blood levels.
• Continue other prescribed heart medicines unless advised otherwise.

Drug Interactions

• CYP3A4 Inhibitors: Ketoconazole and clarithromycin significantly raise ranolazine levels.
• CYP3A4 Inducers: Rifampin and phenytoin reduce ranolazine's effectiveness.
• Digoxin: Increases digoxin blood levels.
• Other QT-Prolonging Drugs: Adds to the risk of irregular heartbeat.

Risks and warnings

• Heart Rhythm Risk: Can prolong the QT interval, requiring caution with other QT-prolonging drugs.
• Not for Acute Attacks: Intended for long-term prevention, not for relieving an acute angina attack.
• Organ Impairment: Dose adjustment is needed with liver or kidney impairment.
• Drug Interactions: Avoid with strong CYP3A4 inhibitors such as certain antifungals and HIV medicines.
• Irregular Heartbeat History: Use with caution if you have a history of arrhythmia.
• Sudden Stopping: Do not discontinue without consulting your doctor.

Angiwell XR Tablet Side Effects

• Dizziness
• Headache
• Constipation
• Nausea
• Weakness
• QT interval prolongation
• Low blood pressure

Storage Conditions

• Store below 30°C in a dry place.
• Keep away from direct sunlight.
• Keep tablets in the original blister pack until use.
• Keep out of reach of children.