Avsar Plus Tablet 160mg/10mg/25mg

About Avsar Plus Tablet 160mg/10mg/25mg

Uses

• Treatment of high blood pressure that stays uncontrolled on a lower diuretic dose combination
• Add on option when the 12.5mg hydrochlorothiazide strength does not reach target blood pressure
• Long term blood pressure control to lower the risk of stroke and heart attack
• Maintenance therapy for patients already stable on this stronger three drug combination

Benefits

• Combines three complementary blood pressure lowering mechanisms in one tablet
• Improves adherence by replacing several separate pills with a single dose
• Delivers a stronger diuretic effect for patients who need it
• Provides steady blood pressure control compared to single drug therapy

What Experts Say

Doctors prescribe this fixed dose combination for hypertension that stays high despite two or more blood pressure medicines. Valsartan blocks angiotensin II to relax blood vessels, amlodipine blocks calcium channels to widen arteries, and hydrochlorothiazide helps the kidneys clear extra salt and fluid.

The 25mg hydrochlorothiazide strength delivers a stronger diuretic effect than the 12.5mg version and is generally used when blood pressure remains uncontrolled on the lower diuretic dose. It is often reserved for patients who have already tolerated the lower strength well or who need more aggressive fluid control.

Because the higher diuretic dose carries a greater chance of low potassium, low sodium and dehydration, doctors usually monitor electrolytes and kidney function more closely on this strength. Blood pressure response is typically reviewed within two to four weeks of starting or adjusting this dose.

Drug Class

• Angiotensin receptor blocker (ARB)
• Calcium channel blocker (dihydropyridine)
• Thiazide diuretic

Avsar Plus Tablet 160mg/10mg/25mg formula

• Valsartan 160mg + Amlodipine 10mg + Hydrochlorothiazide 25mg

Available forms

• Tablet

How to use Avsar Plus Tablet 160mg/10mg/25mg?

• Take one tablet once daily, preferably at the same time every day
• Swallow the tablet whole with a glass of water, with or without food
• Do not stop the medicine suddenly without talking to your doctor
• Your doctor will decide the exact dose based on your blood pressure response

Drug Interactions

• Other blood pressure lowering medicines can increase the risk of hypotension
• NSAIDs like ibuprofen may reduce the blood pressure lowering effect and affect kidney function
• Potassium supplements or potassium sparing diuretics can raise potassium to unsafe levels
• Lithium levels can rise when taken with this combination, raising toxicity risk
• Other ARBs or ACE inhibitors should not be combined with this medicine

Risks and warnings

• May cause low blood pressure, especially after the first dose or in dehydrated patients
• Can affect kidney function, particularly in people with existing kidney disease
• May lower potassium and sodium levels more than the 12.5mg strength because of the higher diuretic dose
• Not safe during pregnancy and should be stopped as soon as pregnancy is confirmed
• Use with caution in patients with liver disease or bile duct problems
• Electrolyte and kidney function monitoring is especially important on this higher diuretic dose

Avsar Plus Tablet 160mg/10mg/25mg Side Effects

• Dizziness or lightheadedness, especially when standing up quickly
• Headache and fatigue
• Mild swelling in the ankles or feet
• Increased urination, more noticeable than with the 12.5mg strength
• Nausea or upset stomach
• Muscle cramps or weakness from electrolyte changes
• Dry cough in some patients

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack