Avsar Plus Tablet 160mg/10mg/12.5mg

About Avsar Plus Tablet 160mg/10mg/12.5mg

Uses

• Treatment of high blood pressure not controlled by two antihypertensive drugs together
• Add on option when an ARB plus calcium channel blocker combination is not enough
• Long term blood pressure control to lower the risk of stroke and heart attack
• Maintenance therapy for patients already stable on this three drug combination

Benefits

• Combines three complementary blood pressure lowering mechanisms in one tablet
• Improves adherence by replacing several separate pills with a single dose
• Offers a lower diuretic dose option to reduce the risk of electrolyte disturbances
• Provides steady blood pressure control compared to single drug therapy

What Experts Say

Doctors prescribe this fixed dose combination when two blood pressure medicines are not enough to bring readings to target. Valsartan relaxes blood vessels by blocking angiotensin II, amlodipine relaxes vessel walls by blocking calcium entry, and hydrochlorothiazide removes excess salt and water through the kidneys.

The 12.5mg hydrochlorothiazide strength is often the preferred starting point for triple therapy because it delivers a meaningful diuretic effect while keeping the risk of low potassium and low sodium lower than the 25mg strength. This makes it a common choice for patients beginning three drug treatment or those sensitive to electrolyte shifts.

Physicians typically monitor kidney function, blood pressure and electrolytes after starting this combination, since all three components can affect fluid balance. If blood pressure remains uncontrolled on this dose, a doctor may consider stepping up to a higher diuretic strength rather than adding a fourth medicine.

Drug Class

• Angiotensin receptor blocker (ARB)
• Calcium channel blocker (dihydropyridine)
• Thiazide diuretic

Avsar Plus Tablet 160mg/10mg/12.5mg formula

• Valsartan 160mg + Amlodipine 10mg + Hydrochlorothiazide 12.5mg

Available forms

• Tablet

How to use Avsar Plus Tablet 160mg/10mg/12.5mg?

• Take one tablet once daily, preferably at the same time every day
• Swallow the tablet whole with a glass of water, with or without food
• Do not stop the medicine suddenly without talking to your doctor
• Your doctor will decide the exact dose based on your blood pressure response

Drug Interactions

• Other blood pressure lowering medicines can increase the risk of hypotension
• NSAIDs like ibuprofen may reduce the blood pressure lowering effect and affect kidney function
• Potassium supplements or potassium sparing diuretics can raise potassium to unsafe levels
• Lithium levels can rise when taken with this combination, raising toxicity risk
• Other ARBs or ACE inhibitors should not be combined with this medicine

Risks and warnings

• May cause low blood pressure, especially after the first dose or in dehydrated patients
• Can affect kidney function, particularly in people with existing kidney disease
• May lower potassium and sodium levels because of the diuretic component
• Not safe during pregnancy and should be stopped as soon as pregnancy is confirmed
• Use with caution in patients with liver disease or bile duct problems
• Regular blood pressure, kidney function and electrolyte monitoring is recommended

Avsar Plus Tablet 160mg/10mg/12.5mg Side Effects

• Dizziness or lightheadedness, especially when standing up quickly
• Headache and fatigue
• Mild swelling in the ankles or feet
• Increased urination
• Nausea or upset stomach
• Muscle cramps or weakness from electrolyte changes
• Dry cough in some patients

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack