Blokium DIU Tablet 100mg/25mg

About Blokium DIU Tablet 100mg/25mg

Drug Class

Blokium DIU Tablet 100mg/25mg belongs to a combination drug class that pairs a cardioselective beta blocker with a thiazide like diuretic, at the maximum labeled dose of this fixed combination. Atenolol slows the heart and eases its workload, while Chlorthalidone helps the kidneys remove excess salt and water.

Blokium DIU Tablet 100mg/25mg Uses in Pakistan

• Controlling hypertension that has not responded fully to the 50mg/12.5mg combination or to single agent therapy
• Managing angina pectoris in patients who need a stronger combined beta blocker and diuretic effect
• Providing the maximum labeled dose of this fixed combination for resistant or harder to control blood pressure
• Reducing cardiovascular strain in patients already stable on lower doses but needing tighter control

What Experts Say

When blood pressure remains difficult to control despite standard combination therapy, clinicians often move to the maximum labeled dose of a fixed combination rather than adding a third separate medicine. This stepwise approach keeps the overall treatment plan simpler while still increasing its effect.

At this higher strength, the beta blocker component provides a stronger and more consistent reduction in heart rate and cardiac workload, while the larger diuretic dose produces a more pronounced reduction in circulating fluid volume. This combined effect is particularly useful for resistant hypertension and for angina that has not settled on lower doses.

Because higher doses carry a greater chance of electrolyte disturbances and a slower than normal heart rate, physicians monitor kidney function, potassium levels and heart rate more closely at this strength. Treatment is usually continued at this dose only as long as it remains well tolerated and clearly effective.

Blokium DIU Tablet 100mg/25mg formula

• Atenolol + Chlorthalidone

Available forms

• Tablet

How to use Blokium DIU Tablet 100mg/25mg?

• Take Blokium DIU exactly as your doctor prescribes, usually once daily in the morning
• Swallow the tablet whole with a glass of water, with or without food
• This higher strength is generally prescribed only once the lower strength has been tried first
• A missed dose should be taken as soon as remembered, without doubling the next one
• Blood tests and blood pressure checks are usually scheduled more closely at this dose
• This medicine should never be stopped without your doctor's guidance

Drug Interactions

• Other blood pressure medicines: Combining with additional antihypertensives can drop blood pressure too low
• NSAID pain relievers: Ibuprofen and diclofenac can reduce the blood pressure lowering effect and stress the kidneys
• Insulin and diabetes tablets: Atenolol can mask the early warning signs of low blood sugar
• Verapamil or diltiazem: Both slow the heart further, raising the risk of an abnormally slow heart rate
• Digoxin: The combination can increase the risk of a very slow heart rhythm
• Lithium: Chlorthalidone can raise lithium levels in the blood to an unsafe range, more so at this higher dose
• Corticosteroids: Long term steroid use combined with this medicine can worsen potassium loss

Risks and warnings

• Asthma or COPD: Atenolol can trigger breathing difficulty in people with airway disease
• Sudden discontinuation: Stopping abruptly can trigger a rebound rise in blood pressure or chest pain
• Diabetes: The usual warning signs of low blood sugar may be harder to notice on this medicine
• Kidney disease: This higher dose needs closer monitoring since both ingredients are cleared through the kidneys
• Gout history: The larger diuretic dose can raise uric acid levels further
• Electrolyte imbalance: A higher chlorthalidone dose carries a greater chance of low potassium or sodium, so routine blood tests matter
• Pregnancy and breastfeeding: Use only if your doctor confirms it is necessary

Blokium DIU Tablet 100mg/25mg Side Effects

• Fatigue or low energy, which can feel more noticeable at this higher dose
• Dizziness or lightheadedness on standing
• Cold hands and feet
• A heart rate that runs slower than normal
• Increased urination and thirst
• Low potassium, sodium or magnesium levels on blood tests
• Muscle cramps or weakness
• Nausea or stomach upset
• Increased sensitivity to sunlight
• A gout flare in people prone to high uric acid
• A mild rise in blood sugar levels

Storage Conditions

Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep tablets in the original blister strip and out of reach of children.