Brophyl Syrup 125 mg

About Brophyl Syrup 125 mg

Brophyl Syrup Uses

• Bronchial asthma
• Chronic bronchitis
• Chronic obstructive pulmonary disease (COPD)
• Wheezing associated with respiratory infections
• Reversible airway obstruction

Brophyl Syrup Benefits

• Airway muscle relaxation helps ease breathing.
• Liquid form suits children and patients who cannot swallow tablets.
• Generally gentler on the stomach than plain theophylline.
• This syrup helps reduce chest tightness and wheeze during flare ups.
• This syrup works alongside inhalers as part of a broader asthma or COPD plan.

What Experts Say

Xanthine derivative bronchodilators remain a familiar option among Pakistani physicians for managing wheeze and breathlessness in asthma, chronic bronchitis and COPD, particularly in patients who need an oral liquid formulation. Acefylline piperazine relaxes the smooth muscle lining the airways, which widens narrowed bronchial tubes and eases the work of breathing.

Compared to plain theophylline, acefylline piperazine is generally better tolerated on an empty or full stomach, which physicians find useful for pediatric and elderly patients who struggle with stricter dosing schedules. It also has a milder stimulant profile on the central nervous system than some older bronchodilators.

Because the therapeutic and toxic doses of xanthine derivatives sit fairly close together, Pakistani physicians stress sticking to the prescribed dose and schedule rather than adjusting it independently. Patients with fever, liver disease or those taking interacting medicines are usually monitored more closely for early signs of overdose such as restlessness or a fast heartbeat.

Drug Class

• Xanthine derivative
• Bronchodilator

Brophyl Syrup 125 mg formula

• Acefylline Piperazine 125mg/5ml

Available forms

• Syrup

How to use Brophyl Syrup 125 mg?

• The bottle should be shaken well before measuring the dose.
• The syrup causes less stomach irritation when given after meals.
• The measuring spoon or cup provided with the pack should be used for accurate dosing.
• The exact dose and frequency prescribed by the doctor should be followed closely.
• The course should not be stopped early, even if breathing feels better.

Drug Interactions

• Ciprofloxacin and Other Fluoroquinolones: These antibiotics can raise blood levels of xanthine derivatives and increase the risk of side effects.
• Cimetidine: This acid reducing medicine can slow the clearance of xanthine derivatives from the body.
• Phenytoin and Rifampin: These medicines can lower blood levels of xanthine derivatives, reducing effectiveness.
• Caffeine: Combining with caffeine containing drinks or medicines can add to restlessness and a fast heartbeat.

Risks and warnings

• Cardiac Conditions: Caution is needed in patients with irregular heartbeat or existing heart disease.
• Peptic Ulcer: Xanthine derivatives can worsen stomach acidity, so caution is needed in patients with active ulcers.
• Seizure Disorder: Caution is needed in patients with a history of seizures, since xanthine derivatives can lower the seizure threshold.
• Fever: High fever can raise blood levels of the drug, increasing the risk of side effects.
• Elderly and Pediatric Use: Dose adjustment is usually needed in young children and elderly patients.

Brophyl Syrup Side Effects

• Nausea or vomiting
• Stomach upset or acidity
• Headache
• Restlessness or difficulty sleeping
• Fast or irregular heartbeat
• Tremors in higher doses

Storage Conditions

• Store below 30°C away from direct heat and sunlight.
• Keep the bottle tightly closed after use.
• Avoid freezing the syrup.
• Keep out of reach of children.
• Discard unused syrup after the expiry date on the pack.