Calpol Plus Tablet 500mg / 65mg

About Calpol Plus Tablet 500mg / 65mg

Calpol Plus Tablet 500mg / 65mg Uses

• Headache and migraine relief
• Toothache and dental pain
• Back pain and muscular pain
• Period pain (dysmenorrhea)
• Cold and flu related body aches
• Fever reduction
• Minor arthritis and joint pain

Calpol Plus Tablet 500mg / 65mg Benefits

• Combines paracetamol with caffeine for faster, stronger pain relief
• Caffeine boosts paracetamol absorption for quicker action
• Effective for tension type headaches and migraines
• Suitable for adults needing fast relief during a busy day
• Non-opioid, with a lower dependency risk than stronger painkillers

What Experts Say

Paracetamol works by reducing prostaglandin production in the brain and spinal cord, which lowers pain signals and helps bring down fever. It does not carry the stomach irritation risks associated with NSAIDs like ibuprofen, making it a common first choice for mild to moderate pain.

Caffeine on its own is not a painkiller, but research shows it works as an adjuvant. Adding caffeine to paracetamol increases its analgesic effect by nearly 40 percent compared to paracetamol alone. Caffeine also speeds up gastric emptying, helping paracetamol reach the bloodstream faster for quicker relief.

This combination is particularly useful for headaches linked to fatigue or reduced alertness, since caffeine has a mild stimulant effect too. Doctors generally recommend staying within the maximum daily paracetamol limit of 4 grams to avoid liver strain, especially when other paracetamol containing products are also being used at the same time.

Drug Class

• Analgesic (Paracetamol, non-opioid pain reliever)
• Antipyretic (fever reducer)
• CNS stimulant and analgesic adjuvant (Caffeine)

Calpol Plus Tablet 500mg / 65mg formula

• Paracetamol + Caffeine

Available forms

• Tablet

How to use Calpol Plus Tablet 500mg / 65mg?

• Take one tablet with a full glass of water
• Adults may take one to two tablets every four to six hours as needed
• Do not exceed 8 tablets (4 grams paracetamol) in 24 hours
• Leave at least 4 hours between doses
• Take with or after food if stomach upset occurs
• Do not use for more than 3 days for fever or 10 days for pain without consulting a doctor
• Avoid taking with other paracetamol containing medicines

Drug Interactions

• Warfarin: Long term regular use of paracetamol may enhance the blood thinning effect of warfarin, increasing bleeding risk.
• Alcohol: Combined use raises the risk of liver toxicity.
• Carbamazepine, Phenytoin and Rifampicin: These enzyme inducing medicines can increase paracetamol breakdown, raising liver damage risk.
• Metoclopramide and Domperidone: These may speed up paracetamol absorption, altering the onset of pain relief.
• Cholestyramine: Can reduce paracetamol absorption if taken together.
• Other caffeine containing products: Combining with tea, coffee, energy drinks or other stimulants can increase jitteriness, insomnia and heart palpitations.

Risks and warnings

• Liver disease: Use with caution in people with existing liver conditions since paracetamol overdose can cause serious liver damage.
• Alcohol use: Regular alcohol consumption increases the risk of liver toxicity when combined with paracetamol.
• Caffeine sensitivity: People with anxiety, palpitations or sleep disorders should use this combination cautiously due to the caffeine content.
• Pregnancy and breastfeeding: Consult a doctor before use since caffeine intake should be limited during pregnancy.
• Children: Not recommended for children under 12 years without medical advice.
• Overdose risk: Avoid combining with other paracetamol containing cold, flu or pain products to prevent accidental overdose.

Calpol Plus Tablet 500mg / 65mg Side Effects

• Nausea or upset stomach
• Difficulty sleeping or restlessness
• Nervousness or jitteriness
• Rapid heartbeat or palpitations
• Dizziness
• Mild allergic skin rash
• Liver damage with prolonged high dose use
• Severe skin reactions in rare cases

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the tablets in their original blister pack until ready to use
• Protect from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack