Ceflactam Injection 250mg/250mg

About Ceflactam Injection 250mg/250mg

Ceflactam Injection 250mg/250mg Uses

• Treats respiratory tract infections such as pneumonia and bronchitis
• Treats urinary tract infections
• Treats skin and soft tissue infections
• Treats intra abdominal infections including peritonitis
• Treats infections of the female reproductive tract
• Treats septicemia and other severe hospital acquired infections

Drug Class

• A third generation cephalosporin antibiotic combined with a beta lactamase inhibitor

What Experts Say

Doctors combine cefoperazone with sulbactam because many bacteria in Pakistan now make enzymes called beta lactamases. These enzymes break down plain cefoperazone before it can work. Sulbactam blocks these enzymes, so cefoperazone stays active against tough strains like Klebsiella and Pseudomonas that often cause hospital infections.

Physicians reserve this combination for moderate to severe infections that need intravenous treatment, since oral antibiotics often fail against multidrug resistant hospital bacteria. Pakistan carries one of the highest burdens of antibiotic resistant infections in the region, which is why culture and sensitivity testing usually guides the decision to start this injection instead of a simpler antibiotic.

Dosing is calculated on body weight and kidney function, since sulbactam clears through the kidneys and can build up when kidney function is reduced. Doctors typically monitor liver enzymes and kidney function during longer courses, and they lower the dose for elderly patients or anyone with existing kidney disease to prevent drug accumulation.

Ceflactam Injection 250mg/250mg formula

• Cefoperazone Sodium 250mg + Sulbactam Sodium 250mg

Available forms

• Injection

How to use Ceflactam Injection 250mg/250mg?

• Given only as an injection into a vein or muscle, never taken by mouth
• Administered by a doctor or nurse in a hospital or clinic setting
• Dose and duration depend on the type and severity of the infection
• Reconstituted with sterile water or saline before it is given
• Usually given every 8 to 12 hours depending on the infection

Drug Interactions

• Blood Thinners: Combining with warfarin or heparin may raise the risk of bleeding
• Alcohol: May cause flushing, nausea, and a fast heartbeat if taken with alcohol during treatment
• Aminoglycoside Antibiotics: Using together with drugs like gentamicin may raise the risk of kidney damage
• Probenecid: May raise cefoperazone levels in the blood and increase side effects
• Live Vaccines: May reduce the effectiveness of live bacterial vaccines such as the typhoid vaccine

Risks and warnings

• Allergy Risk: Avoid this injection if you have had an allergic reaction to penicillin or cephalosporin antibiotics before
• Kidney Function: Needed with caution in kidney disease, since the dose may need adjustment
• Liver Function: Liver enzymes are monitored during longer treatment since cefoperazone clears through the liver
• Bleeding Risk: May affect blood clotting in some patients, so tell your doctor about any unusual bruising or bleeding
• Pregnancy and Breastfeeding: Used only if your doctor confirms the benefit outweighs the risk
• Superinfection: Long courses may lead to a secondary fungal or bacterial infection such as oral thrush

Ceflactam Injection 250mg/250mg Side Effects

• Pain, redness, or swelling at the injection site
• Nausea or vomiting
• Diarrhea or loose stools
• Skin rash or itching
• Fever or chills
• Unusual bleeding or bruising in rare cases
• Severe allergic reaction with swelling of the face or throat in rare cases

Storage Conditions

• Store the unopened vial below 25 degrees Celsius in a cool dry place away from sunlight
• Keep away from children and pets
• Use the reconstituted solution promptly as directed by the pharmacist or nurse
• Do not freeze the reconstituted solution
• Discard any unused portion after the recommended time