Certican tablet 0.25mg

About Certican tablet 0.25mg

Certican tablet 0.25mg Uses

• Prevention of organ rejection after kidney transplant
• Prevention of organ rejection after heart transplant
• Prevention of organ rejection after liver transplant
• Used together with cyclosporine or tacrolimus and steroids

Drug Class

• mTOR inhibitor
• Immunosuppressant

What Experts Say

Everolimus blocks a protein called mTOR that immune cells need to multiply, which reduces the immune system's ability to attack a transplanted organ. It is almost always combined with other immunosuppressants rather than used alone.

Certican tablet is taken twice daily, at the same times each day relative to cyclosporine dosing, exactly as the transplant team directs. Blood levels are checked regularly to keep the dose in a safe and effective range.

Because it suppresses the immune system, it raises the risk of infections and certain cancers with long term use. Any dose change or missed dose should be discussed with the transplant team rather than adjusted alone.

Certican tablet 0.25mg formula

• Everolimus 0.25mg

Available forms

• Tablet

How to use Certican tablet 0.25mg?

• Take exactly as prescribed by the transplant specialist, usually twice daily.
• Take at a consistent time relative to cyclosporine doses.
• Do not stop or change the dose without consulting the transplant team.
• Attend all scheduled blood tests to monitor drug levels.

Drug Interactions

Certican tablet has several important interactions given its narrow safety margin.

• Cyclosporine: Levels of both medicines need close monitoring when combined.
• Strong CYP3A4 inhibitors (ketoconazole, clarithromycin): Significantly raise everolimus levels and toxicity risk.
• Rifampicin and certain anticonvulsants: Reduce everolimus levels and effectiveness.
• Live vaccines: Should be avoided during treatment due to immune suppression.

Risks and warnings

• Infection risk: Increases susceptibility to infections due to immune suppression.
• Wound healing: Can slow wound healing, especially soon after transplant surgery.
• Cancer risk: Long term immunosuppression raises the risk of skin cancer and lymphoma.
• Kidney and lipid effects: Can affect kidney function and raise cholesterol and triglyceride levels.
• Pregnancy: Avoid in pregnancy, as it can harm the unborn baby.

Certican tablet 0.25mg Side Effects

• High cholesterol or triglycerides
• Swelling in the legs or feet
• Mouth ulcers
• High blood pressure
• Low blood counts
• Increased infection risk

Storage Conditions

Store below 30°C in a dry place away from moisture and direct sunlight, out of reach of children.