Clavir Tablet 60mg

About Clavir Tablet 60mg

Clavir Tablet 60mg Uses

• Chronic Hepatitis C virus infection, genotype 1, 2, 3 or 4
• Used together with sofosbuvir as combination antiviral therapy
• Prescribed for patients with or without compensated liver cirrhosis
• Part of Hepatitis C treatment protocols followed in Pakistani gastroenterology clinics

Clavir Tablet 60mg Benefits

• Clears Hepatitis C virus from the blood in most treated patients
• Oral once daily dosing instead of weekly injections
• Shorter treatment course compared to older interferon based therapy
• Lower rate of flu like side effects than injectable regimens

What Experts Say

Liver specialists in Pakistan now treat chronic Hepatitis C with direct acting antivirals like daclatasvir instead of older interferon based injections. This combination clears the virus in most patients within twelve to twenty four weeks, with far milder side effects than earlier regimens.

Doctors stress that daclatasvir must always be paired with sofosbuvir or a similar partner drug, never used alone, since Hepatitis C needs a two pronged attack on the virus. Skipping doses or stopping early lets the virus rebound and can make the next treatment attempt harder to succeed.

Physicians also recommend a baseline liver function test and a heart rhythm check before starting, especially for patients already taking amiodarone or other heart medicines. Most patients tolerate the course well and go on to test negative for the virus at follow up scans, which is why this combination has largely replaced older injectable Hepatitis C treatments in Pakistani clinics.

Drug Class

• NS5A replication complex inhibitor
• Direct acting antiviral used only for Hepatitis C, not for Hepatitis B or HIV

Clavir Tablet 60mg formula

• Daclatasvir

Available forms

• Tablet

How to use Clavir Tablet 60mg?

• Take one tablet by mouth once daily, at roughly the same time each day
• Swallow whole with a glass of water, with or without food
• Always take together with sofosbuvir 400mg as prescribed, never alone
• Complete the full course, usually 12 to 24 weeks, even if you feel well
• Do not skip or double doses, and do not stop early without your doctor's advice

Drug Interactions

Clavir can interact with several common medicines, so share your full medicine list with your doctor.

• Amiodarone: Combination with sofosbuvir/daclatasvir can cause dangerously slow heart rate
• Rifampin: Reduces daclatasvir levels and can make treatment fail
• St. John's Wort: Lowers daclatasvir blood levels, avoid during treatment
• Strong CYP3A4 inducers: Certain seizure medicines can reduce effectiveness

Risks and warnings

• Pregnancy: Not recommended unless the benefit clearly outweighs the risk, discuss with your doctor
• Heart rhythm: Serious slow heartbeat has occurred when combined with amiodarone, needs cardiac monitoring
• Hepatitis B: Can reactivate a dormant Hepatitis B infection, screening is advised before starting
• Liver disease: Use only under specialist supervision if you have advanced cirrhosis

Clavir Tablet 60mg Side Effects

Most people tolerate Clavir well when it is taken alongside sofosbuvir for Hepatitis C treatment.

• Headache
• Fatigue or tiredness
• Nausea
• Diarrhea

Some reactions are rare but need urgent medical attention if they occur.

• Very slow or irregular heartbeat, especially with amiodarone use
• Signs of liver problems such as yellowing of eyes or skin
• Severe allergic reaction with rash, swelling or breathing difficulty

Storage Conditions

• Store below 30 degrees Celsius in a dry place
• Keep the tablets in their original blister pack until use
• Protect from direct sunlight and moisture
• Keep out of reach of children