Clexane Injection 80mg

About Clexane Injection 80mg

Uses

• Treatment of deep vein thrombosis (DVT) with or without pulmonary embolism (PE)
• Prevention of blood clots after major surgery, including hip and knee replacement
• Management of unstable angina and non ST elevation heart attack (NSTEMI)
• Used with other medicines during ST elevation heart attack (STEMI)
• Anticoagulation support during hemodialysis procedures

Benefits

• Reduces the risk of clot related complications after major surgery
• Acts faster than warfarin and needs less frequent lab monitoring
• Can be self administered at home once proper technique is taught
• Lowers the chance of clot extension or recurrence during acute treatment

What Experts Say

Clexane 80mg contains a fixed high dose of enoxaparin sodium, a low molecular weight heparin that works mainly by inhibiting clotting factor Xa. This action slows the clotting cascade and helps prevent further growth of an existing blood clot. Doctors typically reserve this strength for weight based treatment dosing rather than routine prevention.

Because the dose is higher than prophylactic strengths, the bleeding risk is also greater. Regular monitoring of platelet counts and kidney function matters, since reduced renal clearance can allow the drug to build up in the body. Caution is advised in older adults and in anyone with a low body weight.

This strength is commonly used after confirmed deep vein thrombosis, pulmonary embolism, or during the acute phase of a heart attack, often alongside other cardiac medicines. It should never be started without a clear diagnosis and should always be given under medical supervision, with attention to any planned spinal procedures.

Drug Class

• Low Molecular Weight Heparin (LMWH)
• Anticoagulant

Clexane Injection 80mg formula

• Enoxaparin Sodium 80mg

Available forms

• Injection

How to use Clexane Injection 80mg?

• Inject subcutaneously into the fatty tissue of the abdomen, thigh, or outer hip as directed by your doctor
• Alternate the injection site each time to reduce bruising and skin reactions
• Do not rub the injection site after giving the dose
• Use the full amount in the prefilled syringe unless your doctor advises a partial dose
• Complete the full course of treatment even if you start feeling better
• Never inject into a muscle or vein
• Let the syringe sit at room temperature for a few minutes if taken fresh from the fridge

Drug Interactions

• Increased bleeding risk when combined with aspirin, NSAIDs, or other antiplatelet drugs
• Increased bleeding risk with oral anticoagulants such as warfarin
• Should be used cautiously with SSRIs and SNRIs due to added bleeding risk
• Concurrent use with other heparins or thrombolytics raises hemorrhage risk
• Herbal supplements like ginkgo, garlic, and fish oil may increase bleeding tendency
• Dose timing must be coordinated carefully around spinal or epidural anesthesia

Risks and warnings

• Carries a risk of spinal or epidural hematoma if given around spinal anesthesia or lumbar puncture, which can cause lasting nerve damage
• Increases the risk of serious bleeding, including intracranial or retroperitoneal hemorrhage, especially at treatment level doses
• May cause heparin induced thrombocytopenia (HIT), a serious drop in platelet count
• Should be used cautiously in patients with kidney impairment since drug clearance is reduced
• Not recommended in patients with active major bleeding or known bleeding disorders
• Requires careful dose adjustment in patients with prosthetic heart valves
• Use with extra caution in elderly patients and those with low body weight due to higher bleeding risk
• Avoid intramuscular injection as it can cause a hematoma at the injection site

Clexane Injection 80mg Side Effects

• Bruising, pain, or redness at the injection site
• Mild bleeding from gums or nose
• Low platelet count
• Elevated liver enzymes on blood tests
• Nausea or upset stomach
• Fever
• Swelling in the legs or feet
• Unusual tiredness
• Skin rash or itching
• Shortness of breath in rare cases

Storage Conditions

• Store below 25°C, away from direct heat and sunlight
• Do not freeze the prefilled syringe
• Keep the syringe in its original carton to protect from light
• Store out of reach of children
• Do not use if the solution looks discolored or contains visible particles
• Dispose of used syringes safely in a puncture proof container