Co-Extor Tablet 5mg / 160 mg / 25 mg

About Co-Extor Tablet 5mg / 160 mg / 25 mg

Co-Extor Tablet Uses

• Treatment of high blood pressure not controlled by two drug therapy alone
• Long term management of resistant or difficult to control hypertension
• Replacement therapy for patients already stable on the same three components taken separately

Co-Extor Tablet Benefits

• Combines three complementary mechanisms in one tablet for stronger blood pressure control
• Once daily dosing that improves treatment adherence
• Reduces the pill burden compared with taking three separate antihypertensive tablets
• Helps lower long term risk of stroke, heart attack and kidney damage linked to uncontrolled hypertension

What Experts Say

Physicians in Pakistan often prescribe Co-Extor Tablet when blood pressure stays high despite two drug therapy. Amlodipine relaxes vessel walls by blocking calcium entry into smooth muscle. Valsartan blocks angiotensin II receptors, easing constriction and fluid retention. Hydrochlorothiazide helps kidneys remove excess sodium and water.

The fixed dose of 5 mg amlodipine, 160 mg valsartan and 25 mg hydrochlorothiazide reflects standard triple therapy used for resistant hypertension. Patients usually start on lower dose combinations first, then step up once dual therapy proves insufficient. Once daily dosing supports better adherence.

Physicians in Pakistan generally recommend baseline and periodic checks of kidney function, sodium and potassium levels while a patient takes this combination, since the thiazide component can alter electrolyte balance. Blood pressure is rechecked regularly to confirm control. Hypertension remains common and often under treated in general practice.

Drug Class

• Calcium channel blocker (Amlodipine)
• Angiotensin II receptor blocker or ARB (Valsartan)
• Thiazide diuretic (Hydrochlorothiazide)

Co-Extor Tablet 5mg / 160 mg / 25 mg formula

• Amlodipine 5mg + Valsartan 160mg + Hydrochlorothiazide 25mg

Available forms

• Tablet

How to use Co-Extor Tablet 5mg / 160 mg / 25 mg?

• Take Co-Extor Tablet exactly as prescribed by the doctor, usually once daily
• Swallow the tablet whole with a glass of water
• Take it at the same time each day, with or without food
• Do not stop taking it suddenly without medical advice, even if blood pressure feels normal
• Missed doses should be taken as soon as remembered, unless it is close to the next dose

Drug Interactions

• Other antihypertensive drugs: Combining with additional blood pressure medicines can cause excessive drops in blood pressure.
• Potassium supplements or potassium sparing diuretics: May raise blood potassium to unsafe levels when combined with this medicine.
• Lithium: Blood lithium levels can rise, increasing the risk of toxicity when taken together.
• NSAIDs: Regular use of painkillers like ibuprofen or diclofenac can reduce the blood pressure lowering effect and affect kidney function.
• Other ARBs or ACE inhibitors: Should not be combined with valsartan due to increased risk of kidney problems and high potassium.

Risks and warnings

• Pregnancy risk: The valsartan component can cause fetal harm, so this medicine must not be used during pregnancy.
• Low blood pressure: The combined effect of all three drugs can cause dizziness or fainting, especially when standing up quickly.
• Electrolyte disturbance: Hydrochlorothiazide can lower potassium and sodium levels, requiring periodic blood tests.
• Kidney function: Regular monitoring is needed since all three components can affect kidney performance, particularly in patients with existing kidney disease.
• Not for first line therapy: This triple combination is not recommended as initial treatment for patients who have not tried single or dual therapy.
• Liver impairment: Patients with severe liver disease should use this medicine with caution and close supervision.

Co-Extor Tablet Side Effects

• Dizziness or lightheadedness
• Swelling in the ankles or feet
• Headache
• Fatigue or tiredness
• Increased urination
• Nausea
• Muscle cramps
• Low blood pressure symptoms such as fainting
• Abnormal kidney function tests
• Low potassium or sodium levels
• Irregular heartbeat in rare cases
• Allergic skin reactions such as rash or itching

Storage Conditions

• Store below 30 degrees Celsius in a cool, dry place
• Keep the tablet in its original blister pack until ready to use
• Protect from direct sunlight and moisture
• Keep out of reach of children