Co-Olan Capsule 12 mg / 25 mg

About Co-Olan Capsule 12 mg / 25 mg

Co-Olan Capsule 12 mg / 25 mg Uses

• Treatment of depressive episodes associated with bipolar I disorder
• Treatment of treatment resistant depression
• Management of mood symptoms in schizoaffective disorder when prescribed by a psychiatrist

Co-Olan Capsule 12 mg / 25 mg Benefits

• Combines an antipsychotic and an antidepressant for dual action on mood symptoms
• Helps stabilize mood swings in bipolar depression
• May work faster than antidepressants alone in resistant depression
• Single capsule simplifies a complex treatment regimen

What Experts Say

Co-Olan pairs olanzapine, an atypical antipsychotic that balances dopamine and serotonin activity, with fluoxetine, a selective serotonin reuptake inhibitor that increases serotonin availability in the brain. Together, they target both the mood instability and depressive symptoms seen in bipolar depression.

Clinical studies on this combination show it can improve depressive symptoms in bipolar disorder more effectively than either drug used alone, which is why it is specifically approved for bipolar depression and treatment resistant depression rather than routine anxiety or mild low mood.

Because olanzapine can affect weight, blood sugar, and lipid levels, psychiatrists typically monitor these parameters regularly during treatment. Regular follow up also allows the dose to be adjusted for the best balance between symptom control and tolerability.

Drug Class

• Atypical Antipsychotic and SSRI Antidepressant Combination

Co-Olan Capsule 12 mg / 25 mg formula

• Olanzapine + Fluoxetine

Available forms

• Capsule

How to use Co-Olan Capsule 12 mg / 25 mg?

• Take exactly as prescribed by your psychiatrist
• Usually taken once daily in the evening unless advised otherwise
• Swallow the capsule whole with water
• Do not stop suddenly without medical guidance, gradual tapering may be needed
• Attend regular follow up appointments to monitor response and side effects

Drug Interactions

• MAO Inhibitors: Should not be combined due to the serious risk of serotonin syndrome
• Other Serotonergic Drugs: Combining with other antidepressants or triptans increases serotonin syndrome risk
• CNS Depressants: Combined use with alcohol or sedatives increases drowsiness and impaired coordination
• CYP2D6 Substrates: Fluoxetine can raise levels of drugs metabolized by this enzyme, requiring dose caution
• Blood Thinners: Fluoxetine may increase bleeding risk when combined with anticoagulants

Risks and warnings

• Suicidal Thoughts: Antidepressants may increase suicidal thoughts in young adults, especially early in treatment
• Weight Gain: Olanzapine is associated with significant weight gain and metabolic changes
• Diabetes Risk: Can raise blood sugar levels, regular monitoring is recommended
• Elderly Patients with Dementia: Increased risk of stroke and death, not recommended in this group
• Pregnancy: Use only if clearly needed, discuss risks and benefits with your doctor
• Serotonin Syndrome: Risk increases when combined with other serotonergic medicines

Co-Olan Capsule 12 mg / 25 mg Side Effects

• Drowsiness
• Weight gain
• Dry mouth
• Increased appetite
• Nausea
• Insomnia
• Dizziness
• Tremor

Storage Conditions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep the capsule in its original packaging until use
• Keep out of reach of children