Cofrest Syrup

About Cofrest Syrup

Cofrest Syrup Uses

• Cough relief associated with chest congestion.
• Cough relief linked to allergies or the common cold.
• Loosened mucus and easier breathing during a cold.

Cofrest Syrup Benefits

• An antihistamine, a mild bronchodilator, and an expectorant combined in one syrup.
• Cough and nasal or chest congestion eased at the same time.
• Improved sleep during a cold, thanks to combined symptom relief.

What Experts Say

Cofrest Syrup combines Theophylline, a mild bronchodilator, with Diphenhydramine, an antihistamine, along with Ammonium Chloride and Menthol as expectorant and soothing agents. This type of combination is commonly prescribed by Pakistani physicians when a cough is accompanied by congestion and disturbed sleep, since Diphenhydramine also has a mild sedating effect at night.

Cough and cold complaints are extremely common in Pakistani clinics, particularly during seasonal changes and periods of high air pollution. A combination syrup, rather than a single ingredient product, is often the preferred choice when a patient reports both a dry, irritating cough and chest tightness together.

Theophylline's narrow safety margin means physicians usually advise sticking closely to the recommended dose and avoiding it in patients with certain heart rhythm problems. Further evaluation is generally advised for patients with a persistent cough lasting more than one to two weeks, rather than continued self-treatment.

Drug Class

• Antitussive-Expectorant Combination
• Mild Bronchodilator with Antihistamine

Cofrest Syrup formula

• Theophylline 32mg + Diphenhydramine Hydrochloride 8mg + Ammonium Chloride 30mg + Menthol 0.98mg per 5ml

Available forms

• Syrup

How to use Cofrest Syrup?

• A good shake of the bottle before each use helps even out the mixture.
• The marked measuring cup provided gives the most accurate dose.
• After meals is the best time to reduce the chance of stomach upset.
• Doses beyond what the doctor or pharmacist advises should be avoided.

Drug Interactions

• Sedatives and Sleep Medicines: The drowsy effect of Diphenhydramine can increase when combined with these.
• Other Theophylline Containing Products: Combined use raises the risk of theophylline toxicity.
• Certain Antibiotics: Macrolides such as Erythromycin can raise Theophylline blood levels.
• MAO Inhibitors: Combination with Diphenhydramine containing products is not advised for patients on MAO inhibitors.

Risks and warnings

• Heart Conditions: Theophylline needs caution in patients with heart disease or irregular heartbeat.
• Seizure Disorders: Caution is advised in patients with a history of seizures.
• Drowsiness: Diphenhydramine content can cause sedation, so driving or operating machinery is not advised until effects are known.
• Peptic Ulcer: Caution is needed in patients with active stomach ulcers.
• Children: Not recommended for young children without a doctor's specific dosing guidance.

Cofrest Syrup Side Effects

• Drowsiness
• Dry mouth
• Nausea
• Stomach upset
• Restlessness, especially in children
• Headache
• Rapid heartbeat at higher doses
• Dizziness

Storage Conditions

• Store below 25°C in a cool, dry place away from sunlight.
• Keep the bottle tightly closed after each use.
• Avoid refrigerating or freezing the syrup.
• Discard any remaining syrup after the period stated on the label once opened.