Cyclogest Pessary 200mg

About Cyclogest Pessary 200mg

Uses

• Luteal phase support during IVF and ICSI cycles
• Prevention of early pregnancy loss linked to progesterone deficiency
• Management of secondary amenorrhea
• Support after egg retrieval and embryo transfer in assisted reproduction
• Progestogen component of hormone replacement therapy in some protocols

Benefits

• Maintains a receptive uterine lining to support embryo implantation
• Delivers hormone directly to the uterus with fewer systemic effects than oral tablets
• Bypasses extensive liver breakdown seen with oral progesterone
• Can be inserted vaginally or rectally depending on tolerance
• Familiar, well established option in fertility clinics across Pakistan

What Experts Say

Fertility specialists prescribe Cyclogest Pessary 200mg to support the uterine lining after ovulation induction, egg retrieval, or embryo transfer. Progesterone thickens the endometrium and keeps it receptive, since a natural luteal phase defect after IVF stimulation can otherwise lead to early pregnancy loss.

The vaginal or rectal route is preferred over oral progesterone in fertility protocols because it avoids extensive first pass liver metabolism and delivers a more consistent local hormone level directly to the uterus. This is why reproductive endocrinologists favor pessaries over tablets for luteal support, despite the added inconvenience of insertion.

Because progesterone can mask or delay recognition of abnormal bleeding, doctors monitor patients closely during treatment and investigate any unexpected spotting rather than assuming it is a normal side effect. Clinicians also screen for a history of blood clots, liver disease, or hormone sensitive tumors before starting therapy, since these conditions change the risk benefit balance considerably.

Drug Class

• Progestogen (natural, micronised progesterone hormone)

Cyclogest Pessary 200mg formula

• Progesterone 200mg

Available forms

• Pessary

How to use Cyclogest Pessary 200mg?

• Insert one pessary into the vagina, or into the rectum if advised, usually two to three times a day as prescribed
• Wash your hands before and after each insertion
• Insert the pessary as far as comfortably possible using a clean finger
• Continue treatment for the full duration set by your fertility specialist, which may extend into early pregnancy if conception occurs
• Do not stop treatment suddenly without medical advice, since abrupt discontinuation can affect hormone levels
• Some waxy vaginal discharge is expected as the pessary base melts and is not a cause for concern

Drug Interactions

• Rifampicin: This antibiotic speeds up progesterone breakdown in the liver and can reduce its effectiveness
• Carbamazepine and phenytoin: These seizure medicines increase liver enzyme activity and can lower progesterone levels in the blood
• St John's Wort: This herbal supplement can reduce progesterone levels through the same liver enzyme pathway
• Other vaginal products: Using other vaginal medicines or spermicides at the same time is not recommended, since they may affect pessary absorption

Risks and warnings

• Prescription only: Cyclogest Pessary 200mg is a prescription only hormone product and should be used strictly under the supervision of a gynecologist or fertility specialist
• Undiagnosed vaginal bleeding: Do not use until any unexplained vaginal bleeding has been investigated by a doctor, since progesterone can mask an underlying problem
• Liver disease: Avoid use if you have severe liver impairment, since progesterone is broken down by the liver and can worsen existing liver dysfunction
• Breast cancer history: Do not use if you have a known or suspected progesterone sensitive tumor, including certain types of breast cancer
• Blood clot risk: Use with caution if you have a personal history of blood clots in the leg, lung, or elsewhere, since hormone therapy can raise clotting risk
• Pregnancy monitoring: Report any unexpected spotting or bleeding during treatment promptly so complications can be ruled out
• Depression history: Use under closer monitoring if you have a history of depression, since hormonal changes can affect mood
• Diabetes: Blood sugar should be monitored more closely, since progesterone can affect glucose tolerance
• Epilepsy or migraine: Use cautiously, since fluid retention linked to progesterone can worsen these conditions

Cyclogest Pessary 200mg Side Effects

• Vaginal or rectal irritation at the insertion site
• Breast tenderness or swelling
• Bloating and fluid retention
• Drowsiness or dizziness after insertion
• Nausea
• Headache
• Mood changes or irritability
• Abdominal cramping
• Spotting or breakthrough bleeding
• Skin rash or allergic reaction (rare)

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight
• Keep pessaries inside their original foil strip until ready to use
• Avoid storing in the bathroom, since heat and humidity can soften or degrade the pessary
• Keep out of reach of children
• Do not use after the expiry date printed on the pack