Dapa-Met Tablets 5 mg / 850 mg

About Dapa-Met Tablets 5 mg / 850 mg

Dapa-Met Tablets Uses

• Type 2 diabetes mellitus, as an add-on to diet and exercise
• Patients whose blood sugar is not controlled well enough on metformin alone
• Patients whose blood sugar is not controlled well enough on dapagliflozin alone
• Adults who need combined SGLT2 inhibitor and biguanide therapy in one tablet

Dapa-Met Tablets Benefits

• Two complementary mechanisms lower blood glucose from different angles
• Modest weight reduction for some patients alongside glucose control
• A single tablet reduces the total pill burden compared with two separate medicines
• Extended release metformin component keeps drug levels steadier across the day

What Experts Say

Dapagliflozin belongs to the SGLT2 inhibitor class. It blocks glucose reabsorption in the kidney's proximal tubule, so excess sugar leaves the body through urine instead of the bloodstream. This pathway works independently of insulin secretion, adding no extra strain on the pancreas.

Metformin mainly reduces glucose production in the liver and improves insulin sensitivity in muscle and fat tissue. The extended release formulation in this tablet keeps plasma levels steadier across the day and tends to cause fewer gastrointestinal side effects than immediate release metformin.

The combination targets diabetes through two separate pathways, often producing better glycemic control than either ingredient alone at a similar dose. Clinical evidence on dapagliflozin plus metformin combinations shows meaningful HbA1c reductions along with a modest weight benefit from glucosuria. Regular kidney function monitoring remains important, since both components depend on adequate renal clearance.

Drug Class

• SGLT2 Inhibitor (Dapagliflozin)
• Biguanide (Metformin)
• Fixed Dose Combination Antidiabetic

Dapa-Met Tablets 5 mg / 850 mg formula

• Dapagliflozin + Metformin

Available forms

• Tablet

How to use Dapa-Met Tablets 5 mg / 850 mg?

• One tablet is usually taken once daily with the morning meal, unless a doctor prescribes a different schedule.
• Swallowing the tablet whole with a full glass of water, without crushing or chewing it, is the standard method.
• The same time each day is best for maintaining a steady blood level of both medicines.
• A missed dose should not be doubled up; the next dose is simply taken at its regular time.
• Kidney function and blood sugar levels guide the exact dose a doctor prescribes.

Drug Interactions

• Insulin and Sulfonylureas: Combined use raises the risk of hypoglycemia, so dose adjustment is often needed.
• Diuretics: Additional fluid loss from diuretics compounds the dehydration risk already linked to dapagliflozin.
• Iodinated Contrast Dye: A temporary pause in metformin is standard practice around contrast imaging due to acute kidney injury risk.
• Alcohol: Heavy alcohol use raises the risk of lactic acidosis with the metformin component.
• Corticosteroids: Blood sugar control can worsen when steroids are used alongside this combination.
• ACE Inhibitors and ARBs: A combined effect on blood pressure and kidney function calls for closer monitoring.

Risks and warnings

• Kidney Function: Reduced kidney function raises the risk of lactic acidosis from the metformin component and lowers the effectiveness of the dapagliflozin component.
• Ketoacidosis: A rare but serious risk with SGLT2 inhibitors is diabetic ketoacidosis, even when blood sugar looks only mildly elevated.
• Dehydration and Low Blood Pressure: Increased urination from dapagliflozin can worsen dehydration, especially in older adults or those on diuretics.
• Genital and Urinary Infections: A higher risk of yeast infections and urinary tract infections is associated with the SGLT2 inhibitor component.
• Surgery and Imaging Procedures: Temporary discontinuation before major surgery or contrast dye procedures is often necessary due to the metformin component.
• Pregnancy and Breastfeeding: Safety during pregnancy and breastfeeding has not been established, so alternative treatment is usually preferred.

Dapa-Met Tablets Side Effects

• Nausea and mild stomach upset, especially when starting treatment
• Diarrhea or loose stools during the first few weeks
• Increased urination and thirst from the glucose lost through urine
• Genital yeast infections in both men and women
• Urinary tract infections
• Low blood sugar when combined with insulin or other diabetes medicines
• Headache and mild dizziness
• A metallic taste in the mouth, common with metformin
• Vitamin B12 deficiency with long term use
• Rare but serious dehydration or a drop in blood pressure

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight.
• Keep the tablets in their original blister pack until the dose is due.
• Keep the pack out of reach of children.
• Avoid storing in the bathroom or near a kitchen sink where moisture is high.
• Discard any tablets past their printed expiry date.