Dinemic SR Tablet 35mg

About Dinemic SR Tablet 35mg

Dinemic SR Tablet 35mg Uses

• Add on treatment for long term management of stable angina pectoris
• Used when first line anti anginal medicines like beta blockers or calcium channel blockers do not control symptoms fully
• Used in patients who cannot tolerate the standard first line anti anginal drugs
• Helps reduce how often angina episodes occur over time

Dinemic SR Tablet 35mg Benefits

• Improves the heart muscle's ability to use oxygen efficiently when blood flow is reduced
• Does not lower blood pressure or slow the heart rate, so it can be added safely to existing heart medicines
• Sustained release formula allows steady drug levels with twice daily dosing
• May improve exercise tolerance in people living with chronic angina

What Experts Say

Trimetazidine works differently from most anti anginal drugs. It does not widen blood vessels, lower blood pressure or slow the heart rate. Instead it acts inside the heart muscle cell, shifting energy production away from fatty acid oxidation toward glucose metabolism, a pathway that needs less oxygen for the same output during ischemia.

Because of this mechanism, cardiologists prescribe it only as add on therapy, layered on top of a beta blocker, calcium channel blocker or nitrate, never as a first choice on its own. Its benefit builds gradually rather than acting within minutes like a nitrate, so doctors typically reassess symptom control after about three months and stop it if angina has not improved.

Regulators tightened its approved use after data linked long term therapy to parkinsonian symptoms, tremor and gait instability, mainly in older adults with reduced kidney clearance. Physicians screen for existing movement disorders before starting treatment, lower the dose once kidney function declines, and withdraw the drug permanently if tremor or unsteady walking develop.

Drug Class

• Anti ischemic agent
• Piperazine derivative
• Metabolic modulator used as anti anginal therapy

Dinemic SR Tablet 35mg formula

• Trimetazidine Dihydrochloride

Available forms

• Tablet

How to use Dinemic SR Tablet 35mg?

• Take one tablet twice daily with breakfast and dinner unless your doctor advises a different schedule
• Swallow the tablet whole with a full glass of water
• Do not crush, split or chew the tablet since this destroys the sustained release coating
• Take it at the same times every day for steady effect
• Your doctor may lower the dose to once daily if you have reduced kidney function or are elderly
• Continue your other heart medicines as prescribed unless your doctor tells you to stop

Drug Interactions

• Antipsychotics And Metoclopramide: These drugs can cause movement disorders on their own, and taking them together with Dinemic SR may add to the risk of tremor or parkinsonian symptoms
• Levodopa And Antiparkinsonian Drugs: Dinemic SR can worsen or unmask parkinsonian symptoms, which may work against the effect of medicines used to treat Parkinson's disease
• Other Anti Anginal Medicines: No significant interaction confirmed, it is commonly combined with beta blockers, calcium channel blockers and nitrates as add on therapy

Risks and warnings

• Movement Disorders: Stop the medicine and see your doctor right away if you notice tremor, stiffness, slow movement or unsteady walking
• Parkinson's Disease: Not for use in people who already have Parkinson's disease or a similar movement disorder
• Kidney Impairment: Needs a lower once daily dose in moderate kidney disease and must not be used in severe kidney failure
• Elderly Patients: Carries a higher risk of falls from low blood pressure or unsteady movement, use with caution
• Pregnancy And Breastfeeding: Avoid use since safety has not been established in these groups
• Not For Acute Attacks: Does not relieve a sudden angina attack, keep your regular rescue medicine on hand at all times

Dinemic SR Tablet 35mg Side Effects

• Dizziness
• Headache
• Stomach pain
• Diarrhea
• Nausea
• Skin rash
• General weakness
• Palpitations
• Low blood pressure
• Tremor or other parkinsonian symptoms with long term use
• Unsteady walking or frequent falls
• Low platelet count in rare cases
• Liver inflammation in rare cases

Storage Conditions

• Store below 30°C in a cool dry place away from direct sunlight
• Keep the tablets in their original blister strip until ready to use to protect from moisture
• Do not crush, split or chew the tablet since this destroys the sustained release mechanism
• Keep out of reach of children
• Do not use after the expiry date printed on the pack