Dizole Tablet 500mg / 400mg

About Dizole Tablet 500mg / 400mg

Dizole Tablet 500mg / 400mg Uses

• Intestinal amoebiasis and amoebic dysentery
• Asymptomatic amoebic cyst carrier state
• Mixed amoebic and bacterial gut infections
• Follow up treatment after chronic amoebiasis

Dizole Tablet 500mg / 400mg Benefits

• Combines a luminal amoebicide with a tissue acting agent in one tablet
• Lowers the chance of relapse compared to using a single drug alone
• Clears both active amoeba and dormant cysts from the gut
• Offers a practical oral option for uncomplicated cases without hospital admission

What Experts Say

Diloxanide furoate acts mainly inside the bowel, where it kills the cyst forming stage of the amoeba that causes recurring infection. Metronidazole works differently, entering the parasite and disrupting its genetic material, which allows it to reach amoeba that have already invaded the gut wall or other tissues.

Using both together addresses a known weakness of single drug amoebiasis treatment, since tissue acting drugs alone often fail to clear the intestinal cyst stage completely. That gap is exactly why relapse and continued carrier states were common before combination therapy became standard practice in gastrointestinal medicine.

Doctors stress finishing the entire prescribed course, even once symptoms like loose stools settle within a day or two, because stopping early tends to leave surviving cysts behind that can restart the infection later. Follow up stool testing is often advised afterward to confirm the infection has fully cleared before the case is closed.

Drug Class

• Antiprotozoal amoebicide combination
• Nitroimidazole antibiotic component

Dizole Tablet 500mg / 400mg formula

• Diloxanide Furoate 500mg + Metronidazole 400mg

Available forms

• Tablet

How to use Dizole Tablet 500mg / 400mg?

• Take the tablet after meals to reduce stomach upset
• Swallow whole with a full glass of water
• Complete the entire prescribed course even if symptoms improve early
• Space doses evenly through the day as directed
• Avoid alcohol for the full duration of treatment

Drug Interactions

• Alcohol: Causes flushing, nausea, and a rapid heartbeat when combined with metronidazole.
• Warfarin: Increases the blood thinning effect and raises bleeding risk.
• Lithium: Raises lithium blood levels, increasing the risk of toxicity.
• Disulfiram: Combining with metronidazole can trigger a confused or psychotic reaction, so this combination should be avoided.
• Phenytoin and Phenobarbital: Can lower metronidazole blood levels and reduce its effectiveness.
• Cimetidine: Can raise metronidazole blood levels, increasing the risk of side effects.

Risks and warnings

• Pregnancy: Avoid use, especially in the first trimester, unless a doctor advises otherwise.
• Breastfeeding: Avoid use or consult a doctor first, since metronidazole passes into breast milk.
• Alcohol use: Avoid alcohol during treatment and for at least 48 hours after the last dose, since it can cause flushing and a rapid heartbeat.
• Liver disease: Use with caution, since dose adjustment may be needed.
• Nervous system disorders: Use with caution, since prolonged use has been linked with numbness or tingling in the hands and feet.
• Blood disorders: Blood counts should be monitored during long or repeated courses.

Dizole Tablet 500mg / 400mg Side Effects

• Nausea and vomiting
• Metallic taste in the mouth
• Stomach cramps
• Bloating and flatulence
• Diarrhea
• Headache
• Dizziness
• Dark colored urine
• Skin rash (uncommon)
• Numbness or tingling in hands or feet with prolonged use (rare, serious)
• Severe allergic reaction such as swelling or difficulty breathing (rare, serious)

Storage Conditions

• Store below 25°C in a dry place away from direct sunlight
• Keep tablets in the original strip until each dose is due
• Keep out of reach of children
• Discard any tablets left over once the prescribed course ends