Doxium Capsule 500mg

About Doxium Capsule 500mg

Doxium Capsule Uses

• Diabetic retinopathy, protecting small blood vessels in the retina
• Chronic venous insufficiency with leg heaviness, swelling and varicose vein discomfort
• Hemorrhoids and related rectal bleeding or discomfort
• Superficial thrombophlebitis
• Capillary fragility disorders

Doxium Capsule Benefits

• Strengthens capillary walls and reduces vessel permeability
• Reduces blood viscosity for better microcirculation
• Eases leg swelling, heaviness and cramping from venous disease
• Reduces bleeding and discomfort from hemorrhoids
• May slow progression of diabetic retinopathy alongside standard eye care

What Experts Say

Calcium dobesilate, the active ingredient in Doxium Capsule, works by reducing capillary hyperpermeability and normalizing the increased fragility of small blood vessels seen in diabetic retinopathy and chronic venous disease. It also lowers blood viscosity and moderates platelet aggregation, which together improve microcirculation in affected tissues.

Clinical evidence from long term use in Europe and Asia supports its role in reducing retinal microaneurysms and slowing capillary leakage in early to moderate diabetic retinopathy. In venous insufficiency and hemorrhoidal disease, it reduces vessel wall permeability, which eases swelling, heaviness and bleeding tendency.

Despite a generally favorable tolerability profile, calcium dobesilate carries a rare but serious risk of agranulocytosis, a sharp drop in white blood cells that impairs the body's infection defense. This is why the drug remains prescription only, and periodic blood count monitoring is recommended during extended therapy.

Drug Class

• Systemic Vasoprotective
• Capillary Protecting Agent

Doxium Capsule 500mg formula

• Calcium Dobesilate 500mg

Available forms

• Capsule

How to use Doxium Capsule 500mg?

• Take Doxium Capsule exactly as prescribed by your doctor
• Swallow the capsule whole with a full glass of water
• Take with food to reduce stomach upset
• Usual adult dose is 500mg two to three times daily, adjusted by your doctor
• Continue for the full duration prescribed, even if symptoms improve early
• Do not double the dose if a dose is missed

Drug Interactions

• Anticoagulants: Calcium dobesilate may add to the bleeding risk when combined with warfarin or other blood thinners
• Antiplatelet Drugs: Combining with aspirin or clopidogrel may increase bruising and bleeding tendency
• Bone Marrow Suppressing Drugs: Concurrent use with drugs that can lower blood counts may raise the risk of agranulocytosis
• NSAIDs: May slightly increase gastrointestinal irritation and bleeding risk when combined

Risks and warnings

• Agranulocytosis Risk: Rare but serious drop in white blood cells has been reported, usually within the first weeks of treatment
• Pregnancy Caution: Safety in pregnancy is not firmly established, use only if clearly needed and advised by a doctor
• Breastfeeding Caution: Limited data exists, discuss with your doctor before use while breastfeeding
• Kidney Impairment: Use with caution and under medical supervision in patients with significant kidney disease
• Infection Signs: Report fever, sore throat or mouth ulcers immediately, as these may signal a blood disorder

Doxium Capsule Side Effects

• Nausea
• Diarrhea
• Stomach discomfort
• Headache
• Skin rash
• Dizziness
• Fever, report to your doctor promptly
• Sore throat or mouth ulcers, a possible sign of agranulocytosis
• Unusual bruising or bleeding
• Allergic reactions including itching or swelling

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the capsules in their original blister pack away from moisture
• Protect from direct sunlight and heat
• Keep out of reach of children
• Discard any expired or damaged capsules safely