Flazol Infusion 500mg/100ml

About Flazol Infusion 500mg/100ml

Flazol Infusion Uses

• Treatment of serious intra-abdominal infections, including peritonitis and abdominal abscess
• Treatment of skin and soft tissue infections caused by anaerobic bacteria
• Treatment of gynecological infections such as endometritis and pelvic abscess
• Treatment of bacterial septicemia caused by susceptible anaerobic organisms
• Treatment of bone and joint infections
• Treatment of central nervous system infections including bacterial meningitis and brain abscess
• Treatment of lower respiratory tract infections such as pneumonia and empyema
• Treatment of bacterial endocarditis
• Prevention of infection after contaminated or potentially contaminated colorectal surgery

Flazol Infusion Benefits

• Clears anaerobic bacterial infections quickly through direct intravenous delivery
• Reaches therapeutic blood levels fast, useful when a patient cannot take oral medicine
• Works well when combined with other antibiotics for mixed bacterial infections
• Reduces the risk of infection after certain surgical procedures
• Effective against a wide range of anaerobic organisms seen in hospital settings

What Experts Say

Physicians prescribe metronidazole infusion when a patient cannot tolerate oral therapy or when infection severity demands rapid, reliable blood levels. The IV route bypasses gut absorption issues that can occur with severe abdominal infections, ensuring the drug reaches infected tissue at an effective concentration within the first dose.

Dosing is typically calculated on body weight, with standard regimens giving around 500mg every eight hours in adults with normal kidney and liver function. Physicians recommend dose adjustment in patients with significant liver impairment, since metronidazole is metabolized primarily by the liver and reduced clearance can raise the risk of neurological side effects.

Doctors across Pakistan continue to favor metronidazole for mixed aerobic and anaerobic infections because it is usually combined with a second antibiotic that covers gram-negative organisms. Ongoing monitoring for neurological symptoms and blood counts is recommended during longer courses, particularly beyond ten days of continuous therapy.

Drug Class

• Nitroimidazole antibiotic

Flazol Infusion 500mg/100ml formula

• Metronidazole

Available forms

• Infusion

How to use Flazol Infusion 500mg/100ml?

• Given only through intravenous infusion under medical supervision, usually in a hospital or clinic setting
• Standard adult dose is 500mg (100ml) infused slowly over 30 to 60 minutes, typically every 6 to 8 hours
• Dose and duration depend on the type and severity of infection, as determined by the treating doctor
• Complete the full prescribed course even if symptoms improve before all infusion bottles are finished
• Avoid alcohol during treatment and for at least 3 days after the last dose
• Inform the doctor about any liver disease before starting treatment, since dose adjustment may be needed

Drug Interactions

• Alcohol and propylene glycol containing products: Causes a disulfiram like reaction with flushing, nausea, and cramping
• Disulfiram: Using together or within 14 days can cause confusion and psychotic reactions
• Warfarin and other blood thinners: Metronidazole can increase their effect, raising bleeding risk, so clotting levels need closer monitoring
• Lithium: Blood lithium levels can rise to toxic levels during concurrent use
• Phenytoin and phenobarbital: These can speed up metronidazole breakdown, reducing its effectiveness
• Cimetidine: Can slow metronidazole clearance and increase side effect risk
• Busulfan: Metronidazole can raise busulfan levels, increasing toxicity risk

Risks and warnings

• Alcohol interaction: Drinking alcohol during treatment or within 3 days after can cause severe flushing, nausea, vomiting, and stomach cramps
• Neurological effects: Prolonged or high dose use can cause peripheral neuropathy, numbness, or tingling in the hands and feet
• Seizure risk: Rare but serious seizures have been reported, especially in patients with a history of epilepsy
• Liver impairment: Patients with severe liver disease need a reduced dose because metronidazole is cleared mainly by the liver
• Blood disorders: Long term or repeated use can lower white blood cell counts, so blood monitoring may be needed
• Pregnancy caution: Use in the first trimester should be avoided unless clearly necessary and advised by a doctor
• Allergic reaction: Stop the infusion immediately if rash, swelling, or breathing difficulty occurs

Flazol Infusion 500mg/100ml Side Effects

• Nausea and vomiting
• Metallic taste in the mouth
• Loss of appetite
• Headache
• Dizziness
• Diarrhea or stomach cramps
• Dark or reddish brown urine, which is a harmless discoloration
• Pain, redness, or swelling at the injection site
• Numbness or tingling in the hands or feet with prolonged use
• Vaginal or oral yeast infection
• Seizures, rare
• Severe skin reactions such as blistering or peeling skin, rare

Storage Conditions

• Store the unopened infusion bottle at room temperature, between 20°C and 25°C
• Keep away from direct sunlight and excess heat
• Do not freeze the infusion solution
• Check the bottle for particles or discoloration before use, and do not use if the seal is broken
• Use the infusion immediately once the vial is opened or spiked, and discard any unused portion
• Keep out of reach of children
• Store and administer only under the supervision of hospital or clinic staff