Itrazox Capsule 100mg

About Itrazox Capsule 100mg

Itrazox Capsule 100mg Uses

• Ringworm and other tinea infections of the skin
• Fungal nail infections (onychomycosis)
• Oral and esophageal candidiasis
• Vaginal yeast infections
• Systemic fungal infections including aspergillosis, blastomycosis and histoplasmosis
• Pityriasis versicolor

Itrazox Capsule 100mg Benefits

• Broad spectrum activity against many fungal species
• Convenient once daily or pulse dosing for nail infections
• Useful alternative for patients who cannot tolerate other antifungals
• Good absorption when taken with a full meal

What Experts Say

Doctors prescribe itraconazole when a fungal infection has not responded to topical creams, or when it involves nails, hair or deeper tissue layers. Its lipophilic and keratinophilic properties let the drug concentrate in skin, nails and fatty tissue, so treatment effects often continue for weeks after the last capsule is taken.

Because itraconazole strongly inhibits the CYP3A4 enzyme, physicians review a patient's full medicine list before starting therapy to avoid dangerous interactions with certain statins, heart rhythm drugs and sedatives. Liver tests are often recommended before treatment and during longer courses, and the drug is generally avoided in anyone with a history of heart failure due to its effect on heart muscle contraction.

Fungal nail and skin infections are common in hot, humid climates, and self treatment with leftover antifungal capsules is a frequent cause of incomplete cure and recurrence. Specialists recommend confirming the diagnosis with a skin scraping or nail sample before starting itraconazole, since inappropriate use can allow resistant fungal strains to develop over time.

Drug Class

• Triazole antifungal

Itrazox Capsule 100mg formula

• Itraconazole

Available forms

• Capsule

How to use Itrazox Capsule 100mg?

• Take Itrazox Capsule 100mg immediately after a full meal to ensure proper absorption
• Swallow the capsule whole with water, do not chew or crush it
• Complete the full course prescribed by your doctor even if symptoms improve early
• Take at the same time each day to maintain steady blood levels
• Avoid antacids or acid reducing medicines within 2 hours of this capsule

Drug Interactions

• Simvastatin and Lovastatin: Combination is not recommended due to increased risk of muscle breakdown
• Oral Midazolam and Triazolam: Combination can cause excessive sedation and breathing problems
• Ergot Alkaloids: Ergotamine and dihydroergotamine can reach toxic levels causing severe vasospasm
• Cisapride, Pimozide and Quinidine: Combination can cause dangerous heart rhythm changes and is contraindicated
• Rifampin and Rifabutin: These reduce itraconazole blood levels and can make treatment ineffective
• Antacids and Acid Reducers: Proton pump inhibitors and H2 blockers reduce absorption of the capsule form
• Warfarin: Itraconazole can increase blood thinning effect and raise bleeding risk
• Felodipine and Similar Calcium Channel Blockers: Blood levels may rise, causing swelling and low blood pressure

Risks and warnings

• Heart Failure Risk: Itraconazole has a negative effect on heart muscle contraction and should not be used in patients with a history of congestive heart failure or ventricular dysfunction unless the infection is life threatening
• Liver Toxicity: Rare but serious liver injury including liver failure has been reported, doctors may order liver function tests before and during longer courses
• Major Drug Interactions: Should not be combined with certain statins, some heart rhythm medicines, oral midazolam or triazolam, and ergot derivatives due to risk of dangerous blood level increases
• Pregnancy Caution: Not recommended during pregnancy except for life threatening infections, effective contraception is advised during and for 2 months after treatment
• Heart Rhythm Changes: May affect the heart's electrical activity, use with caution alongside other medicines that affect heart rhythm

Itrazox Capsule 100mg Side Effects

• Nausea and vomiting
• Stomach pain or indigestion
• Diarrhea
• Headache
• Dizziness
• Skin rash or itching
• Swelling of the legs or ankles
• Low potassium levels
• Elevated liver enzymes
• Fatigue
• Signs of heart failure such as shortness of breath or sudden weight gain
• Yellowing of skin or eyes indicating liver problems
• Severe allergic reactions including rash with blistering

Storage Conditions

• Store below 30 degrees Celsius in a cool dry place
• Keep the capsules in their original blister pack away from moisture
• Protect from direct sunlight
• Keep out of reach of children
• Do not use after the expiry date printed on the pack