Liometacen Injection 50mg

About Liometacen Injection 50mg

Liometacen Injection Uses

• Acute gouty arthritis flares
• Rheumatoid arthritis pain and swelling
• Osteoarthritis joint pain
• Ankylosing spondylitis inflammation
• Acute bursitis and tendinitis
• Postoperative pain and inflammation
• Severe musculoskeletal pain requiring rapid relief

Liometacen Injection Benefits

• Faster pain relief than oral NSAID tablets
• Effective control of acute inflammatory flares
• Reduces joint swelling and stiffness
• Useful when oral medication is not tolerated well
• Rapid onset suited for urgent pain control in a clinical setting

What Experts Say

Indomethacin belongs to the nonsteroidal anti-inflammatory drug class and works by nonselectively blocking cyclooxygenase-1 and cyclooxygenase-2 enzymes. This lowers prostaglandin synthesis, which reduces pain signaling, tissue swelling, and fever at the site of injury or inflamed joint tissue.

The injectable meglumine indomethacinate salt improves water solubility, allowing faster systemic absorption than oral tablets. Peak plasma levels are reached sooner with intramuscular dosing, which supports its use for rapid relief during acute gout flares or severe inflammatory joint pain episodes.

Indomethacin is considered one of the more potent NSAIDs available, so its strong anti-inflammatory action carries a comparatively higher risk of gastrointestinal irritation and renal strain than newer selective agents. Clinicians generally recommend the lowest effective dose for the shortest duration needed to control symptoms.

Drug Class

• Nonsteroidal Anti-Inflammatory Drug (NSAID)
• Indole Acetic Acid Derivative
• Nonselective COX Inhibitor

Liometacen Injection 50mg formula

• Indomethacin (as Meglumine Indomethacinate) 50mg

Available forms

• Injection

How to use Liometacen Injection 50mg?

• Administered only by a healthcare professional via deep intramuscular injection
• One ampoule (50mg) is typically given for an acute pain episode
• The next dose timing should follow the prescribing doctor's instructions
• The ampoule should be used immediately after opening and any unused solution discarded
• The solution should not be injected if it appears discolored or contains particles
• Any history of stomach ulcer, kidney disease, or heart condition should be reported to the doctor before use

Drug Interactions

• Aspirin And Other NSAIDs: Combined use raises the risk of stomach ulcers and gastrointestinal bleeding.
• Warfarin: Indomethacin increases the anticoagulant effect and bleeding risk.
• Lithium: Indomethacin can raise lithium blood levels, leading to toxicity.
• Methotrexate: Indomethacin can reduce methotrexate clearance and increase toxicity risk.
• ACE Inhibitors And ARBs: Indomethacin can reduce their blood pressure lowering effect and worsen kidney function.
• Diuretics: Indomethacin can reduce diuretic effectiveness and increase the risk of kidney impairment.
• Corticosteroids: Combined use increases the risk of gastrointestinal ulcers.
• Cyclosporine: Indomethacin may increase the risk of kidney toxicity when combined with cyclosporine.

Risks and warnings

• Gastrointestinal Bleeding: Indomethacin can cause stomach ulcers or bleeding, especially with repeated use.
• Kidney Function: Reduced kidney blood flow may worsen kidney function in dehydrated or elderly patients.
• Heart Risk: Long term NSAID use is linked to a higher risk of heart attack and stroke.
• Pregnancy: Not recommended in the third trimester due to risk of fetal heart and kidney complications.
• Injection Site Reaction: Pain, swelling, or induration may occur at the injection site.
• Central Nervous System Effects: Confusion, dizziness, or headache may occur, particularly in elderly patients.

Liometacen Injection Side Effects

• Nausea and stomach upset
• Headache and dizziness
• Injection site pain or swelling
• Heartburn or indigestion
• Drowsiness or fatigue
• Fluid retention and mild leg swelling
• Raised blood pressure
• Stomach ulcer or gastrointestinal bleeding
• Reduced kidney function
• Ringing in the ears
• Mood changes or confusion in elderly patients

Storage Conditions

• Store the ampoules at room temperature between 15°C and 30°C
• Protect the ampoules from direct light and heat
• Keep the injection away from moisture and freezing temperatures
• Store the ampoules inside their original box until use
• Discard any opened or unused ampoule after administration
• Keep out of reach of children