Maladrin tablet 500mg / 25mg

About Maladrin tablet 500mg / 25mg

Maladrin tablet 500mg / 25mg Uses

• Treatment of uncomplicated malaria caused by Plasmodium falciparum
• Used as a single dose treatment in areas with confirmed malaria exposure
• Sometimes used alongside other antimalarial medicines for better effect
• Used in some regions for intermittent preventive treatment during pregnancy under medical guidance

Maladrin tablet 500mg / 25mg Benefits

• Works as a single dose treatment in most uncomplicated cases
• Long acting combination that stays effective in the body for days
• Affordable option for malaria treatment across Pakistan
• Targets the malaria parasite through two combined mechanisms

What Experts Say

Maladrin combines Sulfadoxine and Pyrimethamine, two medicines that block different steps the malaria parasite needs to make folic acid for its own growth. Together they stop the parasite from multiplying and spreading further in the bloodstream.

This combination is mainly used for Plasmodium falciparum malaria, the more dangerous type of malaria found in parts of Pakistan. Because resistance to this combination can develop in some regions, doctors usually confirm the diagnosis with a blood test before starting treatment with it.

People with a known sulfa allergy or G6PD deficiency need special caution, since this combination can trigger serious skin or blood related reactions in those groups. Doctors review a patient's full medical history carefully before prescribing this antimalarial combination, and usually avoid it in people with a prior reaction to sulfa medicines.

Drug Class

• Antifolate antimalarial combination
• Sulfonamide and pyrimidine derivative
• Antiparasitic agent

Maladrin tablet 500mg / 25mg formula

• Sulfadoxine 500mg
• Pyrimethamine 25mg

Available forms

• Tablet

How to use Maladrin tablet 500mg / 25mg?

• Take the tablets exactly as prescribed by your doctor, usually as a single dose
• Swallow the tablets with plenty of water
• Take with food to reduce the chance of stomach upset
• Complete the full course even if you start feeling better
• Seek medical review if fever does not improve within a few days

Drug Interactions

• Folic Acid Supplements: High doses can reduce how well Maladrin works against malaria.
• Other Antifolate Medicines: Combining with similar drugs increases the risk of side effects.
• Blood Thinners: May increase the effect of warfarin, requiring closer monitoring.
• Other Antimalarials: Should only be combined under medical supervision.

Risks and warnings

• Sulfa Allergy: Should be avoided in people with a known allergy to sulfonamide medicines.
• G6PD Deficiency: Can trigger destruction of red blood cells in people with this enzyme deficiency.
• Skin Reactions: Rare but serious skin reactions have been reported with this combination.
• Pregnancy: Use only under medical supervision, especially in the first trimester.
• Blood Disorders: Requires caution in people with existing blood cell disorders.

Maladrin tablet 500mg / 25mg Side Effects

• Nausea or vomiting
• Loss of appetite
• Headache
• Skin rash
• Dizziness
• Rare but serious skin reactions such as blistering
• Blood count changes with prolonged use
• Allergic reactions in sulfa sensitive individuals

Storage Conditions

• Store below 30 degrees Celsius in a dry place
• Keep the tablets in their original packaging
• Protect from moisture and direct sunlight
• Keep out of reach of children