Masacol Tablet 400mg

About Masacol Tablet 400mg

Masacol Tablet 400mg Uses

• Treats mild to moderate acute flare ups of ulcerative colitis
• Maintains remission once ulcerative colitis symptoms settle
• Helps maintain remission in Crohn's ileo colitis
• Reduces inflammation lining the large intestine
• Eases bowel related symptoms during an active flare

Masacol Tablet 400mg Benefits

• Targets inflammation directly in the gut lining
• Delayed release formula reaches the colon intact
• Lowers frequency of diarrhea and abdominal cramping
• Supports long term bowel control with regular use
• Generally better tolerated than older sulfa based options
• Can be used for extended maintenance therapy under supervision

What Experts Say

Mesalazine works topically once it reaches the colon, where the delayed release coating protects it from breakdown higher up in the gut. Physicians recommend swallowing the tablet whole so this coating stays intact and the drug is released where inflammation is actually occurring.

Dosing is typically higher during an active flare and then tapered to a maintenance dose once symptoms settle, a pattern doctors across Pakistan follow closely with inflammatory bowel disease patients. Pakistan carries a notable burden of undiagnosed ulcerative colitis, so consistent dosing and follow up matter for long term control.

Renal function is monitored periodically because mesalazine is cleared through the kidneys and rare interstitial nephritis has been reported. Physicians also weigh cardiac history before prescribing, since hypersensitivity myocarditis has occurred in a small number of patients, making a baseline clinical assessment part of routine practice.

Drug Class

• Aminosalicylate
• Anti-inflammatory bowel agent

Masacol Tablet 400mg formula

• Mesalazine 400mg

Available forms

• Tablet

How to use Masacol Tablet 400mg?

• Swallow the tablet whole with a full glass of water
• Take about one hour before a meal for best absorption
• Do not chew, crush or break the tablet
• Follow the exact dose your doctor sets for flare versus maintenance therapy
• Take doses at evenly spaced times through the day
• Do not stop suddenly once symptoms improve without medical advice
• Keep follow up appointments for blood and kidney tests

Drug Interactions

• Digoxin: Mesalazine may reduce digoxin absorption from the gut.
• Azathioprine or 6-mercaptopurine: Combined use can increase immunosuppressant effects and blood toxicity risk.
• Furosemide or spironolactone: Mesalazine may reduce the diuretic effect of these medicines.
• Warfarin: May alter anticoagulant effect, requiring closer clotting checks.
• NSAIDs: Combined use raises the risk of kidney related side effects.
• Methotrexate: Concurrent use may increase the chance of toxicity.

Risks and warnings

• Salicylate allergy: Avoid use if you have a known hypersensitivity to aspirin or salicylate compounds.
• Kidney disease: Use with caution and regular monitoring since mesalazine can affect renal function.
• Liver impairment: Severe hepatic insufficiency requires medical review before starting therapy.
• Cardiac history: Patients with prior myocarditis or pericarditis need close observation.
• Pregnancy and breastfeeding: Use only if your doctor confirms the benefit outweighs any risk.
• Young children: Not recommended for children under two years of age.
• Blood disorders: Report unusual bruising, fever or sore throat promptly since rare blood cell changes can occur.
• Missed monitoring: Skipping recommended blood tests can delay detection of rare kidney or blood side effects.

Masacol Tablet 400mg Side Effects

• Headache
• Diarrhea
• Abdominal pain
• Nausea
• Vomiting
• Skin rash
• Dizziness
• Joint pain
• Fever
• Reduced appetite
• Blood in urine in rare cases
• Unusual tiredness from rare blood cell changes

Storage Conditions

• Store the tablet blister below 30°C in a dry place
• Protect from direct sunlight and moisture
• Keep in the original blister pack until the dose is due
• Keep out of reach of children