Mendon Tablet 10mg

About Mendon Tablet 10mg

Mendon Tablet 10mg Uses

• Nausea and vomiting from various causes
• Vomiting linked to gastroenteritis
• Bloating and early fullness from delayed stomach emptying
• Nausea and vomiting during chemotherapy or radiotherapy, under medical supervision
• Upper abdominal discomfort linked to gastroparesis

Mendon Tablet 10mg Benefits

• Speeds up stomach emptying so food moves into the intestine faster
• Reduces the urge to vomit by blocking signals in the brain's vomiting center
• Eases bloating and a heavy, full feeling after meals
• Does not cross into the brain easily, so it causes less drowsiness than older anti nausea drugs

What Experts Say

Domperidone works by blocking dopamine D2 receptors in the stomach wall and in the brain's chemoreceptor trigger zone. This speeds up gastric emptying and reduces nausea signals reaching the vomiting center. Because domperidone does not easily cross the blood brain barrier, it causes less drowsiness than older antiemetics such as metoclopramide.

Regulatory reviews have linked domperidone to a small rise in heart rhythm disturbances, mainly at higher doses, in older adults, and when combined with other medicines that affect heart rhythm. Because of this, guidelines recommend the lowest effective dose for the shortest duration, usually not more than one week, with an ECG advised for patients who already have heart disease.

Clinicians usually avoid domperidone in people with significant liver or kidney impairment, since reduced clearance can raise blood levels and heart risk. It is also avoided with strong CYP3A4 inhibitors and other QT prolonging drugs. Pregnant women, breastfeeding mothers, and children under 12 years or under 35 kilograms need dosing decided by a doctor.

Drug Class

• Prokinetic agent
• Dopamine D2 receptor antagonist
• Antiemetic

Mendon Tablet 10mg formula

• Domperidone Maleate

Available forms

• Tablet

How to use Mendon Tablet 10mg?

• Take Mendon Tablet 10mg about 15 to 30 minutes before meals and, if needed, before bedtime
• Swallow the tablet whole with a glass of water
• Follow the dose and duration your doctor prescribes, usually up to 3 times a day
• Do not take more than the prescribed dose or use it for longer than 1 week without medical review

Drug Interactions

• Ketoconazole And Other Azole Antifungals: Raise domperidone blood levels and increase heart rhythm risk
• Macrolide Antibiotics Such As Erythromycin: Increase the risk of QT prolongation
• Other QT Prolonging Drugs: Combining raises cardiac risk
• Anticholinergic Medicines: Can reduce the stomach emptying effect of domperidone
• Strong CYP3A4 Inhibitors: Increase domperidone concentration in the blood

Risks and warnings

• Heart Rhythm Risk: Domperidone can prolong the QT interval and raise the risk of serious heart rhythm problems, especially at higher doses
• Not For Long Term Use: Treatment is usually limited to one week because of cardiac safety concerns
• Liver Or Kidney Disease: Doses need to be reduced and use should be closely supervised
• Elderly Patients: Older adults are more sensitive to heart rhythm side effects
• Children: Not recommended for children under 12 years or under 35 kilograms except under specialist guidance

Mendon Tablet 10mg Side Effects

• Dry mouth
• Headache
• Stomach cramps
• Diarrhea
• Skin rash or itching
• Breast tenderness or unusual milk production
• Irregular heartbeat or palpitations
• Fainting or severe dizziness

Storage Conditions

• Store below 30 degrees Celsius in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep the strip in its original packaging until use
• Keep out of reach of children