Micazol Tablet 250mg / 200mg

About Micazol Tablet 250mg / 200mg

Micazol Tablet Uses

• Treats intestinal amoebiasis caused by Entamoeba histolytica
• Clears amoebic dysentery with blood and mucus in stool
• Manages giardiasis and other protozoal gut infections
• Used for asymptomatic carriers who pass amoebic cysts in stool
• Supports treatment of mixed anaerobic bacterial and parasitic gut infections

Micazol Tablet Benefits

• Combines a tissue acting drug with a luminal acting drug in one tablet
• Clears both active infection and cyst carriage, lowering relapse risk
• Reduces further spread of infection to family members through contaminated food or water
• Convenient fixed dose combination compared to taking two separate medicines

What Experts Say

Metronidazole is a nitroimidazole that gets activated inside anaerobic organisms, where it damages the DNA of amoebic trophozoites and other susceptible microbes. This clears active tissue infection quickly, but it does not reliably reach amoebic cysts sitting in the intestinal lumen.

Diloxanide furoate works differently. Once absorbed in the gut, it converts to free diloxanide, which acts locally on the bowel wall to kill these luminal cysts. Combining both drugs in one tablet closes this gap, treating active infection and the carrier state together, which is why fixed dose combinations like this are generally preferred over metronidazole alone for confirmed amoebiasis.

Clinical improvement usually appears within a few days, but the full course should be completed to prevent relapse and further spread through contaminated food or water, a common transmission route in Pakistan. Anyone with high fever, blood in stool, or symptoms lasting beyond a few days needs prompt medical evaluation rather than repeating the same course without medical advice.

Drug Class

• Antiamoebic Combination
• Nitroimidazole (Metronidazole Component)
• Luminal Amoebicide (Diloxanide Furoate Component)

Micazol Tablet 250mg / 200mg formula

• Diloxanide Furoate 250mg + Metronidazole 200mg

Available forms

• Tablet

How to use Micazol Tablet 250mg / 200mg?

• Take exactly as prescribed by your doctor, usually two tablets three times a day after meals
• Swallow the tablet whole with a full glass of water
• Complete the entire course even if symptoms improve within a few days
• Avoid alcohol during treatment and for at least 48 hours after the last dose
• Do not double the dose if a dose is missed; take the next dose at the usual time

Drug Interactions

• Alcohol And Disulfiram: Combining these with metronidazole can trigger severe flushing, nausea, and vomiting
• Warfarin And Other Blood Thinners: Metronidazole can raise their effect, increasing the risk of bleeding
• Lithium: Levels can rise, so doctors usually monitor kidney function and lithium levels closely
• Phenytoin And Phenobarbital: These may lower metronidazole levels by speeding up its breakdown in the liver
• Cimetidine: May raise metronidazole levels in the blood, so a lower dose might be needed

Risks and warnings

• Pregnancy: Avoid during the first trimester unless your doctor considers it clearly necessary
• Alcohol Use: Can cause a severe reaction with flushing, nausea, and vomiting because of the metronidazole component
• Liver Disease: Needs dose adjustment since both components are processed by the liver
• Prolonged Use: Extended courses have been linked to numbness, tingling, or seizures in rare cases
• Breastfeeding: Metronidazole passes into breast milk, so a short pause in feeding may be advised

Micazol Tablet Side Effects

• Nausea, vomiting, or stomach upset
• Metallic taste in the mouth
• Loss of appetite
• Headache or dizziness
• Dark colored urine
• Skin rash or itching
• Numbness or tingling in hands and feet with prolonged use
• Rare but serious allergic reactions including facial swelling or difficulty breathing

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack