Mirabet Tablet 25mg

Mirabet Tablet Uses

Mirabet tablet may be prescribed for:

• Overactive bladder
• Urinary urgency
• Frequent urination
• Night-time urination
• Urinary incontinence
• Reduced bladder capacity
• Bladder control issues
• Bladder discomfort

What Experts Say

Mirabegron, the active compound in Mirabet, belongs to the beta-3 adrenergic agonist class of medicines. It selectively activates beta-3 adrenergic receptors found in the detrusor muscle of the bladder. This activation causes the muscle to relax during the filling phase of the bladder cycle.

Unlike older antimuscarinic medicines used for overactive bladder, Mirabet works through a different mechanism. This makes it a suitable alternative for patients who cannot tolerate antimuscarinics or have not responded to them. Clinical trials have shown that Mirabet reduces the number of daily urinations and incontinence episodes compared to placebo.

Mirabegron is absorbed from the gastrointestinal tract and reaches peak blood concentrations within approximately one to three hours. It is processed by the liver and excreted primarily through urine, with a half-life of around 50 hours.

Dosage and Administration

• Adults: One tablet once daily, with or without food
• Swallow the tablet whole with a full glass of water
• Do not crush, split, or chew the tablet
• Take at the same time each day for best results
• Typical treatment course: 4 to 8 weeks, with dosage review by the doctor
• Children: Safety and dosage must be determined by a doctor

Drug Class

• Beta-3 Adrenergic Agonist
• Genitourinary Smooth Muscle Relaxant

Packaging and Quantity

• Pack size: 20 extended-release tablets per pack
• Each tablet contains the active ingredient mirabegron

When Not to Use Mirabet

• Known allergy to mirabegron or any component of this medicine
• Severe uncontrolled high blood pressure
• Severe kidney impairment
• Severe liver impairment
• Pregnancy or breastfeeding, unless specifically advised by a doctor

Missed Dose

If a dose of Mirabet is missed, it should be taken as soon as it is remembered. However, if more than 12 hours have passed since the scheduled dose, the missed dose should be skipped. The next dose should be taken at the regular time. Double doses should not be taken to compensate for a missed one.

Overdose

In cases of suspected Mirabet overdose, medical attention should be sought immediately. An overdose may cause elevated blood pressure, a rapid heart rate, and palpitations. There is no specific antidote, and management is supportive. Blood pressure, pulse rate, and heart rhythm should be monitored by a healthcare provider.

Food Interactions

• No clinically significant food interactions have been identified with Mirabet
• The tablet may be taken with or without food
• Alcohol: The interaction with Mirabet is not fully established; moderation is advisable

How Long Does Mirabet Take to Work

Patients may begin to notice some improvement in bladder symptoms within a few weeks of starting Mirabet. The full benefit of treatment is usually seen after four to eight weeks of consistent use. Individual response may vary, and a doctor should be consulted if no improvement is observed.

Laboratory Tests While Using Mirabet

Periodic blood pressure monitoring is recommended during Mirabet treatment, as this medicine can cause a modest increase in blood pressure. Patients with pre-existing hypertension should be monitored more closely. Blood levels of certain co-administered medicines may also need to be checked.

Mirabet Tablet 25mg formula

• Mirabegron

Available forms

• Tablets

Risks and warnings

• Blood pressure: Mirabet may cause a modest rise in blood pressure; patients with hypertension should have blood pressure monitored regularly
• Urinary retention: Use with caution in patients with bladder outflow obstruction or those already taking antimuscarinic medicines
• Liver impairment: Mirabet should not be used in patients with severe liver impairment; dose adjustment may be needed in moderate impairment
• Kidney impairment: Use is not recommended in patients with severe kidney impairment
• Pregnancy: The safety of Mirabet in pregnancy has not been fully established; it should be used only if the benefit clearly outweighs the risk
• Breastfeeding: It is unknown whether Mirabet passes into breast milk; it should be used with caution in breastfeeding women
• Elderly patients: Mirabet can be used in elderly patients, though monitoring for blood pressure and heart rate is advisable
• Heart conditions: Patients with a history of heart disease or stroke should inform their doctor before starting Mirabet
• Glaucoma: Patients with a history of narrow-angle glaucoma should use Mirabet with caution
• Allergic reactions: Discontinue immediately if signs of a serious allergic reaction develop and seek emergency care

How to use Mirabet Tablet 25mg?

• Read the medication guide provided by the pharmacist before starting Mirabet
• Take one tablet by mouth once daily, at the same time each day
• Mirabet may be taken with or without food
• Swallow the tablet whole with a full glass of water
• Do not crush, break, or chew the tablet, as this may cause the medicine to release too quickly
• Continue taking Mirabet for as long as directed by the doctor, even if symptoms improve
• Do not stop treatment without consulting a doctor first
• If a dose is missed and more than 12 hours have passed, skip that dose and resume the normal schedule

Mirabet Tablet Side Effects

Most patients tolerate Mirabet well at recommended doses. Side effects, when they occur, are usually mild and temporary.

• Increased blood pressure
• Headache
• Dry mouth
• Nausea
• Constipation
• Diarrhoea
• Urinary tract infection
• Rapid heart rate (tachycardia)

Serious side effects are uncommon. A doctor should be contacted immediately if any of the following occur:

• Severe allergic reaction: swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; skin rash or hives
• Inability to pass urine
• Signs of Stevens-Johnson syndrome: severe skin blistering or peeling, particularly with fever
• Confusion, hallucinations, or significant changes in mental state
• Significant or sustained rise in blood pressure

Contraindications

Mirabet should not be used in the following cases:

• Known allergy to mirabegron or any component of this medicine
• Severe uncontrolled high blood pressure
• Severe kidney impairment
• Severe liver impairment
• Pregnancy or breastfeeding, unless specifically advised by a doctor

Drug Interactions

Mirabet may interact with the following drugs:

• Digoxin: Mirabegron may increase digoxin blood levels; the lowest effective digoxin dose should be used and levels monitored
• Warfarin: Mirabegron may slightly increase warfarin blood levels; INR monitoring is recommended
• Metoprolol and desipramine: Mirabegron may increase blood levels of medicines metabolised by the CYP2D6 enzyme
• Thioridazine, flecainide, propafenone: Caution is required when these narrow therapeutic index CYP2D6 substrates are used alongside Mirabet
• Tamsulosin: Mirabegron may increase tamsulosin exposure; use with caution
• Ozanimod: Combined use may increase blood pressure and heart rate; avoid if possible

Storage Conditions

• Store at room temperature, below 25 degrees Celsius
• Keep away from direct sunlight, heat, and moisture
• Store in the original packaging until use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack
• Do not store in the bathroom or near a sink