Mirabet Tablet 50mg

About Mirabet Tablet 50mg

Mirabet Tablet 50mg Uses

• Treating overactive bladder (OAB) symptoms
• Reducing sudden, urgent need to urinate
• Decreasing frequent urination during the day
• Managing urge urinary incontinence (leakage)
• Improving bladder control at night (nocturia)

Mirabet Tablet 50mg Benefits

• Relaxes the bladder muscle to increase storage capacity
• Works differently from antimuscarinic OAB drugs, causing less dry mouth
• Can be combined with antimuscarinic drugs for added symptom control
• Improves quality of life and daily routine
• Generally well tolerated for long term use

What Experts Say

Mirabegron belongs to a class of medicines called beta-3 adrenergic agonists. It works by relaxing the detrusor muscle in the bladder wall during the storage phase of the urinary cycle. This action increases the bladder capacity to hold urine and reduces the sudden urge to void. Unlike older overactive bladder medicines, it does not block muscarinic receptors, so dry mouth and constipation are less common with this drug.

Clinical trials have shown mirabegron significantly reduces the number of incontinence episodes and daily urination frequency compared with placebo. Doctors often prescribe it when antimuscarinic drugs such as oxybutynin or solifenacin cause intolerable side effects or fail to control symptoms adequately. It can also be combined with these drugs for added effect in resistant cases.

Mirabegron can raise blood pressure in some patients, so doctors usually check blood pressure before starting treatment and periodically during therapy, especially in those with existing hypertension. Response to treatment is generally assessed after four to eight weeks, and the dose may be increased if tolerated and needed for adequate symptom relief.

Drug Class

• Beta-3 adrenergic agonist
• Urinary antispasmodic (bladder relaxant)

Mirabet Tablet 50mg formula

• Mirabegron

Available forms

• Tablet

How to use Mirabet Tablet 50mg?

• Take one tablet once daily, with or without food.
• Swallow the tablet whole with a glass of water.
• Do not crush, chew or split the tablet.
• Take at the same time each day for consistent effect.
• Continue for as long as your doctor recommends, even if symptoms improve early.

Drug Interactions

• Digoxin: Mirabegron can raise digoxin blood levels, so dose monitoring is needed when used together.
• CYP2D6 Substrates: Mirabegron can increase levels of drugs like metoprolol and desipramine that are broken down by this enzyme.
• Antimuscarinic OAB Drugs: Combining with solifenacin or oxybutynin may increase the risk of urinary retention.
• Warfarin: May alter the anticoagulant effect, requiring closer monitoring of blood clotting tests.
• Beta Blockers: Concurrent use may increase the risk of high blood pressure and irregular heartbeat.

Risks and warnings

• High Blood Pressure: Mirabegron can raise blood pressure, so it should be avoided in patients with severe uncontrolled hypertension.
• Urinary Retention: Use with caution in patients with bladder outlet obstruction, as it may cause inability to empty the bladder.
• Kidney or Liver Impairment: Dose adjustment or avoidance is needed in patients with severe kidney or liver disease.
• Angioedema: Stop the medicine and seek medical help if swelling of the face, lips, tongue or throat occurs.
• Pregnancy and Breastfeeding: Use only if clearly needed and advised by a doctor, as safety data is limited.

Mirabet Tablet 50mg Side Effects

• Headache
• Increased blood pressure
• Nasopharyngitis (common cold like symptoms)
• Urinary tract infection
• Dizziness
• Dry mouth
• Constipation
• Nausea
• Fast or irregular heartbeat (palpitations)
• Fatigue
• Urinary retention (rare)
• Allergic reaction with facial swelling (rare)

Storage Conditions

• Store below 30°C in a cool, dry place.
• Keep the tablets in their original blister pack until use.
• Protect from direct sunlight and moisture.
• Keep out of reach of children.
• Discard unused tablets after the expiry date.