Moksi Tablet 400mg

About Moksi Tablet 400mg

Moksi Tablet Uses

• Treatment of acute bacterial sinusitis
• Treatment of community acquired pneumonia
• Treatment of acute bacterial exacerbation of chronic bronchitis
• Treatment of skin and soft tissue infections
• Treatment of complicated intra abdominal infections

Moksi Tablet Benefits

• Broad spectrum coverage against gram positive and gram negative bacteria
• Once daily dosing improves patient adherence
• Effective against many respiratory pathogens resistant to older antibiotics
• Good tissue penetration supports faster symptom resolution

What Experts Say

Moxifloxacin belongs to the fourth generation fluoroquinolone class of antibiotics. It works by inhibiting two bacterial enzymes, DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, repair, and transcription. Blocking these enzymes prevents bacteria from multiplying and leads to bacterial cell death.

Its broad spectrum activity covers many gram positive organisms including Streptococcus pneumoniae, along with several gram negative and atypical respiratory pathogens. This wide coverage makes it a useful option for respiratory tract infections where multiple bacterial species may be involved, though appropriate use is essential to slow the development of antibiotic resistance.

Pharmacokinetic studies show moxifloxacin achieves high concentrations in lung tissue and body fluids, supporting once daily dosing. Its interaction with cardiac ion channels explains the associated QT prolongation risk, which is why clinicians screen for underlying heart rhythm disorders and concurrent QT prolonging medications before starting therapy.

Drug Class

• Fluoroquinolone Antibiotic (Fourth Generation)

Moksi Tablet 400mg formula

• Moxifloxacin Hydrochloride

Available forms

• Tablet

How to use Moksi Tablet 400mg?

• Take one tablet daily as prescribed, usually for 5 to 14 days depending on the infection.
• Swallow the tablet whole with a full glass of water.
• Take with or without food at the same time each day.
• Avoid taking antacids, calcium, iron, or zinc supplements within 4 hours of this medicine.
• Complete the full course even if symptoms improve earlier.

Drug Interactions

• Antacids And Multivalent Cations: Products containing magnesium, aluminum, calcium, iron, or zinc reduce moxifloxacin absorption and should be separated by several hours.
• QT Prolonging Drugs: Combining with antiarrhythmics, certain antipsychotics, or other QT prolonging medicines raises the risk of dangerous heart rhythm disturbances.
• Corticosteroids: Concurrent use increases the risk of tendonitis and tendon rupture, especially in older adults.
• Warfarin: May enhance the anticoagulant effect and increase bleeding risk, requiring closer monitoring.
• NSAIDs: Combined use may increase the risk of central nervous system stimulation and seizures.
• Antidiabetic Agents: Can alter blood glucose control, causing either hypoglycemia or hyperglycemia.

Risks and warnings

• Tendon Rupture: Risk of tendonitis and tendon rupture increases in elderly patients and those taking corticosteroids.
• QT Prolongation: This medicine can prolong the heart's QT interval and should be avoided in patients with known heart rhythm disorders.
• Peripheral Neuropathy: Nerve damage causing numbness, tingling, or weakness can occur and may be permanent in rare cases.
• CNS Effects: May cause dizziness, confusion, or seizures, particularly in patients with a history of central nervous system disorders.
• Not For Children: Avoid use in children and growing adolescents due to the risk of joint and cartilage damage.

Moksi Tablet Side Effects

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Taste disturbances
• Tendon pain or swelling
• Rash or itching
• Elevated liver enzymes
• Insomnia or sleep disturbances
• Irregular heartbeat in susceptible patients

Storage Conditions

• Store below 30°C in a dry place away from direct sunlight.
• Keep the tablets in their original packaging until use.
• Keep out of reach of children.
• Protect from excess moisture and heat.
• Dispose of any unused or expired tablets safely.