Natrilix SR Tablet 1.5mg

About Natrilix SR Tablet 1.5mg

Natrilix SR Tablet 1.5mg Uses

• Treatment of essential hypertension (high blood pressure)
• Long term blood pressure control in adults
• Reduction of stroke risk in patients with a history of cerebrovascular disease, often combined with an ACE inhibitor
• Adjunct therapy alongside other antihypertensive medicines when blood pressure remains uncontrolled

Natrilix SR Tablet 1.5mg Benefits

• Provides steady 24 hour blood pressure control with a single daily dose
• Sustained release formula reduces peak plasma fluctuations compared to standard indapamide
• Lower incidence of electrolyte disturbance compared to older high dose thiazide diuretics
• Supports reduced risk of stroke and cardiovascular events when blood pressure is well controlled
• Largely neutral effect on blood sugar and cholesterol levels, suitable for long term use

What Experts Say

Indapamide is classified as a thiazide type diuretic, though its antihypertensive effect extends well beyond simple diuresis. At the low 1.5mg dose used in this tablet, it works mainly by relaxing peripheral blood vessels through calcium channel modulation and improved arterial compliance, producing only mild natriuresis.

The sustained release design slows drug release into the bloodstream, keeping plasma indapamide levels more stable across 24 hours. Immediate release indapamide given at higher single doses carries a greater risk of hypokalemia and other electrolyte shifts, while the SR form allows a lower total daily dose with comparable blood pressure control.

Clinical outcome data support indapamide for cardiovascular risk reduction, especially when combined with an ACE inhibitor, where the combination has shown a meaningful reduction in recurrent stroke among patients with a prior cerebrovascular event. Its largely neutral effect on glucose and lipid metabolism makes it suitable for long term diuretic therapy.

Drug Class

• Thiazide type diuretic (indoline derivative)

Natrilix SR Tablet 1.5mg formula

• Indapamide

Available forms

• Tablet

How to use Natrilix SR Tablet 1.5mg?

• Take one tablet by mouth once daily, preferably in the morning
• Swallow the tablet whole with a full glass of water
• Do not crush, chew, or split the tablet since it is a sustained release formulation
• Take it at the same time each day for consistent blood pressure control
• Can be taken with or without food
• Do not stop taking this tablet suddenly without consulting a doctor

Drug Interactions

• Lithium: Indapamide can reduce lithium clearance and raise lithium blood levels, increasing the risk of lithium toxicity.
• Other Antihypertensive Drugs: Combining with other blood pressure medicines can cause an additive drop in blood pressure.
• NSAIDs: Nonsteroidal anti inflammatory drugs such as ibuprofen or diclofenac may reduce the antihypertensive effect and raise the risk of kidney problems.
• QT Prolonging Drugs: Medicines such as certain antiarrhythmics (amiodarone, sotalol) carry a higher risk of dangerous heart rhythm problems if electrolyte imbalance occurs alongside indapamide.
• Digoxin: Low potassium caused by indapamide can increase the risk of digoxin toxicity.
• Corticosteroids: Long term steroid use combined with indapamide can worsen potassium loss.
• Metformin: Dehydration from diuretic use combined with metformin can raise the risk of lactic acidosis, particularly in patients with reduced kidney function.
• Baclofen: This muscle relaxant can increase the blood pressure lowering effect of indapamide, raising the risk of dizziness or fainting.

Risks and warnings

• Electrolyte Imbalance: Indapamide can lower sodium and potassium levels, particularly hyponatremia and hypokalemia, so periodic blood tests are recommended especially during the first weeks of treatment.
• Kidney Function: Use with caution in patients with impaired kidney function since diuretics can worsen renal performance in severe cases.
• Liver Disease: Patients with liver impairment carry a higher risk of hepatic encephalopathy if electrolyte imbalance occurs, so this tablet should be used carefully in such cases.
• Photosensitivity: This medicine may increase skin sensitivity to sunlight, so sun exposure should be limited and sunscreen used during treatment.
• Gout Risk: Indapamide can raise uric acid levels and may trigger a gout flare in susceptible patients.
• Pregnancy And Breastfeeding: This tablet is generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor.
• Sulfonamide Allergy: Patients with a known sulfonamide allergy should inform their doctor before starting this medicine due to possible cross sensitivity.
• Elderly Patients: Older adults are more prone to electrolyte disturbances and low blood pressure, so closer monitoring is advised.

Natrilix SR Tablet 1.5mg Side Effects

• Dizziness
• Headache
• Fatigue or weakness
• Muscle cramps
• Nausea
• Constipation
• Dry mouth
• Mild skin rash
• Low potassium levels (hypokalemia)
• Low sodium levels (hyponatremia)
• Irregular heartbeat linked to significant electrolyte imbalance
• Severe allergic reaction with swelling of the face, lips, or throat (rare)
• Severe skin reactions including blistering or peeling (rare)
• Pancreatitis with severe stomach pain (rare)
• Unusual bleeding or bruising due to blood cell changes (rare)

Storage Conditions

• Store below 30°C in a cool dry place
• Keep the tablet in its original blister pack until ready to use
• Protect from direct sunlight, heat, and moisture
• Keep out of reach of children
• Discard any unused tablets after the expiry date printed on the pack