Novonorm Tablet 1mg

About Novonorm Tablet 1mg

Novonorm Tablet Uses

• Control of high blood sugar in adults with type 2 diabetes
• Use alongside diet and exercise when lifestyle changes alone are not enough
• Combination therapy with metformin when metformin alone is insufficient
• Management of after meal blood sugar spikes

Novonorm Tablet Benefits

• A fast onset of action matched to mealtime dosing
• A short duration that lowers the risk of prolonged low blood sugar between meals
• Flexible dosing, with a dose skipped along with a skipped meal
• An option for some people with mild to moderate kidney impairment, under medical guidance

What Experts Say

Repaglinide belongs to the meglitinide class of oral antidiabetic medicines. It works by binding to potassium channels on pancreatic beta cells, triggering a quick burst of insulin release right around mealtimes. This mechanism closely follows the body's own natural first phase insulin response to food.

Its fast onset and short half life set it apart from sulfonylureas, which act over a longer stretch of the day. This profile lets the dosing schedule track meal timing closely, so a skipped meal generally means a skipped dose rather than a fixed daily schedule.

Repaglinide is metabolized mainly by the liver, so caution is needed in people with significant hepatic impairment, and blood sugar should be monitored closely when it is combined with other glucose lowering medicines. Regular monitoring helps balance effective blood sugar control against the risk of hypoglycemia.

Drug Class

• Meglitinide, a non-sulfonylurea insulin secretagogue

Novonorm Tablet 1mg formula

• Repaglinide

Available forms

• Tablet 1mg

How to use Novonorm Tablet 1mg?

• One tablet 15 to 30 minutes before a main meal
• No dose if a meal is skipped, to avoid low blood sugar
• An extra dose only if an extra meal is added, and only as advised by a doctor
• The tablet with a glass of water
• Regular blood sugar checks as advised while on this medicine

Drug Interactions

• Gemfibrozil: A significant rise in repaglinide levels and severe hypoglycemia risk make this combination generally avoided.
• Clopidogrel: Higher repaglinide exposure and hypoglycemia risk with combined use.
• CYP3A4 inhibitors (such as ketoconazole, clarithromycin): Repaglinide blood levels can rise with combined use.
• CYP3A4 inducers (such as rifampicin): Repaglinide effectiveness can drop with combined use.
• Beta blockers: The warning signs of low blood sugar can be masked with combined use.

Risks and warnings

• Low blood sugar: Repaglinide can cause hypoglycemia, especially when a meal is delayed or skipped.
• Liver disease: Closer monitoring is needed in significant liver impairment.
• Kidney disease: Dose adjustment may be needed in reduced kidney function.
• Pregnancy and breastfeeding: Limited safety data means a doctor's advice is needed before use.
• Elderly patients: Increased sensitivity to blood sugar lowering effects may need a dose adjustment.
• Gemfibrozil use: A dangerous rise in repaglinide levels can occur with this combination, generally avoided.

Novonorm Tablet 1mg Side Effects

• Low blood sugar (hypoglycemia)
• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Upper respiratory tract infection symptoms
• Weight gain
• Joint pain

Storage Conditions

• Store below 25°C in a dry place
• Keep the blister strip away from direct light and moisture
• Keep out of reach of children
• Discard tablets after the expiry date printed on the pack