Pepzym Tablet

About Pepzym Tablet

Pepzym Tablet Uses

• Indigestion (dyspepsia)
• Bloating and excess gas
• Pancreatic enzyme insufficiency
• Delayed stomach emptying
• Post-operative digestive discomfort
• Nausea related to slow gut motility

Pepzym Tablet Benefits

• Combines a prokinetic with digestive enzymes for broader digestive relief
• Helps break down proteins and fats for better nutrient absorption
• Reduces gas-related bloating and discomfort
• Supports bile flow for smoother digestion

What Experts Say

Metoclopramide works as a dopamine D2 receptor antagonist that increases gastric motility and speeds stomach emptying, explaining its role for patients with sluggish digestion. Pancreatin and bromelain supply digestive enzymes that assist protein breakdown when the body's own enzyme output is reduced, while simethicone works mechanically to break down trapped gas bubbles.

Sodium dehydrocholate is a bile salt derivative that promotes bile secretion, supporting fat digestion alongside the enzyme components, so the combination is generally prescribed for functional dyspepsia, bloating and mild pancreatic enzyme insufficiency. Doctors typically limit metoclopramide containing products to short courses because of its central nervous system activity.

Extended or high dose use of metoclopramide carries a recognized risk of extrapyramidal movement symptoms and tardive dyskinesia, which is why this product is prescription only and treatment courses are generally kept to twelve weeks or less. Doctors usually reassess ongoing digestive symptoms rather than continue metoclopramide based therapy indefinitely.

Drug Class

• Prokinetic Agent
• Digestive Enzyme Supplement
• Antiflatulent

Pepzym Tablet formula

• Metoclopramide + Sodium Dehydrocholate + Bromelain + Simethicone + Pancreatin

Available forms

• Tablet

How to use Pepzym Tablet?

• Take one to two tablets with meals, or as directed by your doctor.
• Swallow the tablet whole with water during or immediately after eating.
• Do not take on an empty stomach.
• Do not use for longer than the doctor-recommended duration without review.

Drug Interactions

• CNS Depressants (Sedatives, Alcohol): May increase drowsiness when combined with metoclopramide.
• Antipsychotic Medicines: Combined use raises the risk of extrapyramidal side effects.
• Digoxin: Metoclopramide may reduce digoxin absorption from the gut.
• Anticholinergic Drugs: May reduce the prokinetic effect of metoclopramide on stomach emptying.

Risks and warnings

• Movement Disorders: Long-term or high-dose use of the metoclopramide component carries a risk of extrapyramidal symptoms and tardive dyskinesia.
• Neurological Conditions: Avoid in patients with epilepsy or Parkinson's disease unless specifically advised by a doctor.
• Gastrointestinal Obstruction: Do not use if bowel obstruction, perforation or active gastrointestinal bleeding is suspected.
• Pregnancy and Breastfeeding: Use only under medical supervision, since metoclopramide crosses into breast milk.

Pepzym Tablet Side Effects

• Drowsiness
• Restlessness
• Diarrhea
• Dry mouth
• Headache
• Muscle stiffness or tremor with prolonged use
• Allergic skin reaction in rare cases

Storage Conditions

• Store below 30°C in a cool, dry place away from moisture.
• Keep the tablets in their original blister pack until use.
• Keep out of reach of children.
• Do not use after the expiry date printed on the pack.