Progrel AP Tablet 75mg/75mg

About Progrel AP Tablet 75mg/75mg

Progrel AP Tablet Uses

• Prevention of blood clots after a heart attack (myocardial infarction)
• Prevention of stent thrombosis after coronary artery stent placement
• Management of unstable angina and non ST elevation heart attack (NSTEMI)
• Secondary prevention after ischemic stroke or transient ischemic attack in selected patients
• Reducing cardiovascular risk in peripheral arterial disease

Progrel AP Tablet Benefits

• Lowers the risk of a second heart attack after cardiac stenting
• Reduces the chance of stroke recurrence in patients with prior ischemic events
• Supports long term artery patency after angioplasty
• Combines two antiplatelet mechanisms in one tablet for easier daily dosing
• Backed by strong clinical evidence in reducing major cardiovascular events

What Experts Say

Dual antiplatelet therapy combines two different mechanisms of platelet inhibition. Aspirin blocks the COX-1 enzyme and reduces thromboxane A2 production, while clopidogrel blocks the P2Y12 receptor on platelets. Together, this combination lowers the chance of a new clot forming inside a coronary stent or a narrowed artery, more effectively than either drug used alone.

Cardiologists across Pakistan commonly prescribe this combination for a defined period after a heart attack, unstable angina, or coronary stent placement. Guidelines generally support six to twelve months of dual therapy after a drug eluting stent, with shorter courses sometimes used after a bare metal stent. The exact duration depends on individual bleeding risk, kidney function, and how the stent was placed.

Pakistan carries a high burden of premature coronary artery disease, often appearing a decade earlier than in Western populations. This makes strict adherence to dual antiplatelet therapy especially important after a cardiac event. Stopping either medicine early without medical advice raises the risk of stent thrombosis, a sudden and dangerous blockage, so physicians stress that any change in this therapy should only happen under direct cardiology supervision.

Drug Class

• Antiplatelet combination
• Clopidogrel: P2Y12 receptor blocker (thienopyridine class)
• Aspirin: cyclooxygenase (COX) inhibitor, salicylate class

Progrel AP Tablet 75mg/75mg formula

• Clopidogrel + Aspirin

Available forms

• Tablet

How to use Progrel AP Tablet 75mg/75mg?

• Take Progrel AP Tablet once daily, at the same time every day, with or without food
• Swallow the tablet whole with a glass of water, do not crush or chew it
• Take exactly as prescribed by your cardiologist, do not adjust the dose yourself
• Do not stop this medicine suddenly without medical advice, even if you feel well
• If a dose is missed, take it as soon as remembered unless it is close to the next dose
• Inform every doctor and dentist that you are taking this medicine before any procedure

Drug Interactions

• NSAIDs: Ibuprofen, diclofenac, and other NSAIDs taken together with this medicine raise the risk of stomach and intestinal bleeding.
• Anticoagulants: Warfarin, rivaroxaban, and other blood thinners combined with this medicine significantly increase overall bleeding risk.
• Proton Pump Inhibitors: Omeprazole and esomeprazole can reduce the activation of clopidogrel through the CYP2C19 enzyme, making it less effective; pantoprazole is a safer alternative when acid suppression is needed.
• SSRIs: Antidepressants like fluoxetine and sertraline can add to the bleeding risk when combined with this medicine.
• Other Antiplatelets: Combining this medicine with additional antiplatelet drugs without medical supervision further raises bleeding risk.
• Methotrexate: High dose aspirin can raise methotrexate levels in the blood and increase its toxicity.

Risks and warnings

• Bleeding Risk: This combination increases the risk of bleeding, including bruising, nosebleeds, and in rare cases serious internal or brain bleeding.
• Surgery Precaution: Tell your surgeon and dentist about this medicine well in advance, since it usually needs to be stopped five to seven days before a planned procedure unless your cardiologist advises otherwise.
• Stent Thrombosis Risk: Stopping this medicine early after stent placement can cause sudden, life threatening clotting inside the stent, never stop without your cardiologist's approval.
• Stomach Ulcer Risk: Long term use can irritate the stomach lining and increase the risk of ulcers or gastrointestinal bleeding, especially with a prior ulcer history.
• Rare Blood Disorder: Clopidogrel has rarely been linked to thrombotic thrombocytopenic purpura, a serious clotting disorder that needs urgent treatment.
• Reye Syndrome Caution: Do not give this medicine to children or teenagers recovering from a viral infection, since the aspirin component carries a Reye syndrome risk.
• Pregnancy And Breastfeeding: Use only if clearly advised by your doctor, since safety data in pregnancy is limited and aspirin is generally avoided in the third trimester.
• Kidney Or Liver Impairment: Use with caution and closer monitoring in patients with significant kidney or liver disease.

Progrel AP Tablet 75mg/75mg Side Effects

• Easy bruising or minor bleeding from cuts
• Nosebleeds
• Upset stomach, heartburn or indigestion
• Diarrhea or constipation
• Headache or dizziness
• Skin rash or itching
• Black or tarry stools, a sign of internal bleeding
• Vomiting blood or material that looks like coffee grounds
• Unusual weakness, pale skin, or shortness of breath from blood loss
• Signs of a severe allergic reaction such as facial swelling or difficulty breathing
• Prolonged bleeding from a wound that does not stop with normal pressure

Storage Conditions

• Store below 30°C in a cool, dry place away from direct sunlight
• Keep the tablets in their original blister pack until ready to use
• Keep out of reach of children
• Do not use after the expiry date printed on the pack
• Do not store in the bathroom or near a sink where moisture can reach it