Prothiaden Tablet 75 mg

About Prothiaden Tablet 75 mg

Uses

• Maintenance treatment of moderate to severe depression
• Mixed anxiety and depression once an initial lower dose has been tolerated
• Sometimes continued longer term for relapse prevention under medical review

Benefits

• Provides a fuller antidepressant effect once the dose has been built up gradually
• Helps sustain improvement in mood, sleep, and anxiety over the course of treatment
• Once daily night time dosing supports better adherence for long term use

What Experts Say

75mg daily is the usual maintenance dose of dosulepin used for moderate to severe depression once a lower starting dose has already been tolerated. It is rarely the first dose a patient is given, because tricyclic agents carry meaningful cardiac risk when taken in excess of the prescribed amount.

At this higher strength, prescribers pay closer attention to blood pressure, heart rhythm, and anticholinergic symptoms such as dry mouth, blurred vision, urinary hesitancy, and constipation, since these effects tend to become more noticeable as the dose rises toward the therapeutic range.

Response to treatment is reviewed regularly at this dose, and abrupt stopping is avoided because dosulepin can cause withdrawal symptoms. Doses above this maintenance range are generally reserved for closely supervised hospital settings rather than routine outpatient care in Pakistan.

Drug Class

• Tricyclic antidepressant (TCA)

Prothiaden Tablet 75 mg formula

• Dothiepin Hydrochloride 75mg

Available forms

• Tablet

How to use Prothiaden Tablet 75 mg?

• Take exactly as prescribed by your doctor, usually as a single dose at bedtime
• Swallow the tablet whole with a glass of water
• Can be taken with or without food
• Do not stop suddenly without medical advice, taper gradually as directed
• Continue taking regularly even after mood improves, unless your doctor advises otherwise
• If a dose is missed, take it when remembered unless it is close to the next dose

Drug Interactions

• Must not be combined with MAOI antidepressants, a gap of at least two weeks is required between the two
• Increased risk of serotonin syndrome with SSRIs and other serotonergic antidepressants
• Additive sedation with alcohol, benzodiazepines, and other sedating medicines
• Increased risk of heart rhythm problems with other drugs that prolong the QT interval, such as certain antiarrhythmics and antipsychotics
• Effects may be increased by drugs that inhibit its metabolism, including some antifungals
• Additive anticholinergic effects with other anticholinergic medicines
• Caution with adrenaline and related sympathomimetic drugs due to cardiovascular effects

Risks and warnings

• Not recommended soon after a heart attack or in people with significant heart rhythm problems
• Can worsen suicidal thoughts, particularly in young adults and during dose changes
• Use with caution in glaucoma, urinary retention, and enlarged prostate
• May lower the seizure threshold in people with epilepsy
• Caution advised in liver disease and in elderly patients, lower doses may be preferred
• Avoid in pregnancy and breastfeeding unless clearly advised by a doctor
• Dangerous in overdose due to effects on the heart, keep away from children
• May impair alertness, avoid driving or operating machinery until effects are known

Prothiaden Tablet 75 mg Side Effects

• Drowsiness and sedation
• Dry mouth
• Constipation
• Blurred vision
• Dizziness or lightheadedness on standing up
• Weight gain
• Sweating
• Difficulty passing urine
• Fast or irregular heartbeat
• Fine tremor

Storage Conditions

• Store below 25°C in a cool, dry place
• Keep the strip in its original packaging away from direct sunlight
• Keep out of reach of children, overdose can be dangerous
• Do not use after the expiry date printed on the pack