PZA-Ciba Tablet 500mg

About PZA-Ciba Tablet 500mg

Uses

• Treatment of tuberculosis (TB) affecting the lungs and other body parts
• Part of the intensive phase of combination TB therapy
• Used alongside isoniazid, rifampicin and ethambutol in the DOTS program
• Prescribed for new and previously treated TB cases under specialist guidance
• Helps shorten total TB treatment duration when combined with other drugs

Benefits

• Kills TB bacteria that other drugs cannot reach inside cells
• Lowers the risk of TB relapse when taken for the full course
• Works well in acidic environments like inflamed lung tissue
• Supported by Pakistan's National TB Control Program for free distribution

What Experts Say

Doctors in Pakistan prescribe Pyrazinamide as part of a four-drug combination during the first two months of TB treatment. This intensive phase targets bacteria hiding inside cells, an area where other TB drugs struggle to work. Pakistan carries one of the highest TB burdens in the world, so completing the full course matters for public health.

Regular blood tests for liver function are a routine part of TB treatment, since this drug can affect the liver in some patients. Patients with liver disease, gout or diabetes need closer monitoring throughout the course. Missing doses is one of the biggest reasons drug-resistant TB develops in Pakistan, so consistent dosing matters.

Pakistan's National TB Control Program offers free TB medicines, including Pyrazinamide combinations, at government health facilities across Lahore, Karachi, Islamabad and Rawalpindi. Families of TB patients often benefit from screening too, since the infection spreads through airborne droplets. A TB specialist should supervise the full treatment course for best results.

Drug Class

• Anti-tuberculosis (anti-TB) agent
• Pyrazinamide derivative

PZA-Ciba Tablet 500mg formula

• Pyrazinamide

Available forms

• Tablet

How to use PZA-Ciba Tablet 500mg?

• Take PZA-Ciba tablets exactly as prescribed by your TB specialist or physician
• Swallow the tablet with a full glass of water, with or without food
• Take doses at the same time each day to maintain steady drug levels
• Complete the entire prescribed course even if symptoms improve early
• Never adjust the dose or stop treatment without medical advice

Drug Interactions

• Rifampicin: Combined use increases the risk of liver toxicity, so monitoring is needed
• Allopurinol: May reduce control of high uric acid levels caused by Pyrazinamide
• Alcohol: Raises the chance of liver damage when taken together
• Other TB drugs: Isoniazid and ethambutol are commonly combined but require liver monitoring

Risks and warnings

• Liver problems: Can cause liver inflammation, especially with prolonged use or existing liver disease
• Gout flare: May raise uric acid levels and trigger joint pain in susceptible people
• Pregnancy: Use only if your doctor confirms the benefits outweigh potential risks
• Alcohol use: Increases the risk of liver damage during treatment
• Drug resistance: Skipping doses can lead to resistant TB strains that are harder to treat

PZA-Ciba Tablet 500mg Side Effects

• Nausea and loss of appetite
• Joint pain from raised uric acid
• Liver enzyme changes on blood tests
• Fatigue and general weakness
• Skin rash or itching
• Yellowing of skin or eyes in rare cases
• Fever
• Stomach upset

Storage Conditions

• Store below 25°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Store out of reach of children
• Keep in the original packaging until use