Sinaxamol Tablet 35mg/450mg

About Sinaxamol Tablet 35mg/450mg

Sinaxamol Tablet Uses

• Muscle spasms and the pain that comes with them.
• Musculoskeletal pain from injuries such as sprains and strains.
• Back pain linked to muscle tightness or spasm.
• Short term pain relief following muscle strain from physical activity or poor posture.

Sinaxamol Tablet Benefits

• Combines a muscle relaxant with a pain reliever in a single tablet.
• Addresses both the muscle spasm and the pain it causes, rather than treating pain alone.
• Convenient two to three times daily dosing for short term muscle pain episodes.
• Familiar Paracetamol component adds fever reducing action alongside pain relief.
• Long established combination with a wide history of use for musculoskeletal pain.

What Experts Say

Sinaxamol combines Orphenadrine Citrate, an anticholinergic agent that blocks acetylcholine signaling in the central nervous system, with Paracetamol, a central pain and fever reliever. Orphenadrine also affects NMDA and histamine H1 receptors, and together these actions reduce muscle tone and ease the spasms that often accompany musculoskeletal injuries.

Paracetamol addresses the pain itself by acting on pain and temperature regulating centers in the brain, without the anticholinergic or muscle relaxing effects of Orphenadrine. Combining the two treats both the spasm and the pain it produces, which is why Sinaxamol is generally used for muscle related pain rather than pain from inflammation alone.

Orphenadrine's anticholinergic action is also responsible for its mild sedative effect, which is why Sinaxamol can cause drowsiness in some patients. Paracetamol is processed almost entirely in the liver, so the same overdose risks that apply to Paracetamol alone also apply to the Paracetamol component of Sinaxamol.

Drug Class

• Muscle Relaxant with Analgesic

Packaging and Quantity

• Pack of 100 tablets (10 strips of 10 tablets each).

When Not to Use Sinaxamol

• If you have a known allergy or hypersensitivity to Orphenadrine, Paracetamol, or any ingredient in the tablet.
• If you have myasthenia gravis, since Orphenadrine can worsen muscle weakness in this condition.
• If you have narrow-angle glaucoma.
• If you have significant difficulty urinating due to an enlarged prostate or urinary retention.

Sinaxamol Tablet 35mg/450mg formula

• Paracetamol + Orphenadrine Citrate

How to use Sinaxamol Tablet 35mg/450mg?

• Sinaxamol tablet should be taken with milk or food to reduce the risk of stomach upset.
• The tablet should be swallowed whole with a glass of water.
• The usual adult dose is one tablet two to three times daily, as directed by a doctor.
• Sinaxamol tablet is generally intended for short term use during an active muscle spasm or pain episode.
• The total daily Paracetamol intake should not exceed the recommended limit, including from other Paracetamol containing products.
• The dose should not be increased or the course extended beyond what a doctor has recommended.

Drug Interactions

Sinaxamol tablet's interactions come from both its muscle relaxant and its pain reliever components. The following should be noted:

• CNS Depressants and Alcohol: Combining Orphenadrine with alcohol, benzodiazepines, or opioid pain relievers can increase sedation and the risk of excessive drowsiness.
• Liver Enzyme Affecting Medicines: Ketoconazole and Phenytoin can alter how Paracetamol is processed by the liver.
• Other Paracetamol Containing Products: Many cold, flu, and pain medicines already contain Paracetamol, so combining them with Sinaxamol tablet can lead to an accidental overdose.
• Warfarin: Regular use of Sinaxamol tablet alongside Warfarin can increase its blood thinning effect.

Risks and warnings

• Liver toxicity: Taking more Paracetamol than recommended, including from other combined products, can cause serious liver damage.
• Sedation: Sinaxamol tablet can cause drowsiness, so driving or operating machinery should be avoided until its effects are known.
• Myasthenia gravis: Orphenadrine's anticholinergic effect can worsen muscle weakness in this condition.
• Glaucoma: Sinaxamol tablet should be avoided in patients with narrow-angle glaucoma.
• Urinary retention: Men with an enlarged prostate may find urination more difficult while taking Sinaxamol tablet.
• Elderly patients: Older adults may be more sensitive to Orphenadrine's confusion and anticholinergic effects.
• Pregnancy: Sinaxamol tablet should only be used during pregnancy when clearly needed and directed by a doctor.

Sinaxamol Tablet Side Effects

Orphenadrine's anticholinergic action tends to drive most of what patients notice with Sinaxamol tablet, including:

• Drowsiness.
• Dry mouth.
• Blurred vision.
• Dizziness.

Effects that call for prompt medical attention are less common but include:

• Yellowing of the skin or eyes, which may signal liver involvement.
• Confusion or significant difficulty urinating.
• Severe allergic reaction including facial swelling or difficulty breathing.

Storage Conditions

• Store at room temperature, below 30°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original packaging until ready to use.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the packaging.
• Do not store in the bathroom or near a kitchen sink.