Sitaglu - Met XR tablet 50mg / 1000mg

About Sitaglu - Met XR tablet 50mg / 1000mg

Sitaglu-Met XR Tablet Uses

• Control of blood sugar in adults with type 2 diabetes, along with diet and exercise.
• Treatment when metformin or sitagliptin alone has not controlled blood sugar enough.
• Replacement for taking sitagliptin and metformin as two separate tablets.
• Lowering of high HbA1c levels, as prescribed.

Sitaglu-Met XR Tablet Benefits

• Two medicines in one tablet reduce the number of pills each day.
• Extended release metformin is gentler on the stomach than plain metformin.
• Low risk of causing blood sugar to fall too low when used alone.

What Experts Say

Sitagliptin raises the body's own insulin after meals and lowers the liver's sugar output. Metformin lowers glucose made by the liver and helps the body respond better to insulin. The two work in different ways, so together they often control sugar better than either one alone. This is why the pair is a common choice when one medicine is not enough.

The extended release design lets metformin enter the blood slowly through the day. Many people with plain metformin stomach upset find this form easier to tolerate. The tablet should be swallowed whole so that slow release is not lost. Taking it with food further lowers stomach upset.

Kidney function should be checked before starting and at least once a year. Pancreatitis and lactic acidosis are rare but serious risks, so severe stomach pain or deep, rapid breathing needs urgent care. Many people in Pakistan fast during Ramadan, so the dose timing should be reviewed with the doctor. Regular HbA1c checks show how well the plan is working.

Drug Class

• Dipeptidyl peptidase 4 (DPP 4) inhibitor with biguanide

Sitaglu - Met XR tablet 50mg / 1000mg formula

• Sitagliptin
• Metformin Hydrochloride (Extended Release)

Available forms

• Extended Release Tablet

How to use Sitaglu - Met XR tablet 50mg / 1000mg?

• Take as prescribed, usually once daily with the evening meal.
• Swallow the tablet whole with water, and do not crush, chew or split it.
• The doctor may start with one or two tablets daily, depending on kidney function and sugar levels.
• Do not change the dose without medical advice, and keep up diet and regular exercise.
• The empty tablet shell may appear in stool, which is normal.

Drug Interactions

• Insulin and sulfonylureas: Combined use can cause low blood sugar, so the doctor may lower their dose.
• Alcohol: Heavy drinking raises the risk of lactic acidosis and low blood sugar.
• Iodinated contrast dye: Metformin may need to be paused around imaging tests.
• Topiramate and acetazolamide: They can raise the risk of lactic acidosis.
• Cimetidine and diuretics: They may change metformin levels or affect kidney function.
• Digoxin: Sitagliptin may slightly raise digoxin levels, so monitoring is advised.

Risks and warnings

• Lactic acidosis: Rare but serious, and more likely with kidney or liver disease, heavy alcohol use or dehydration.
• Pancreatitis: Stop the medicine and seek urgent care for severe, lasting stomach pain.
• Kidney function: Dose changes or stopping may be needed if kidney function falls.
• Contrast dye and surgery: Metformin is usually paused before scans with iodine dye and before major surgery.
• Pregnancy and breastfeeding: Insulin is generally preferred in pregnancy, so consult a doctor first.
• Vitamin B12: Long term metformin use can lower B12, so periodic checks help.

Sitaglu-Met XR Tablet Side Effects

• Nausea
• Diarrhea
• Stomach pain or bloating
• Gas
• Headache
• Metallic taste
• Upper respiratory infection
• Low blood sugar when combined with insulin or sulfonylureas

Storage Conditions

• Store below 30 C in a dry place, away from heat and humidity.
• Keep tablets in the original blister until use.
• Do not use after the expiry date on the pack.
• Keep out of reach of children.