Sofohil tablets 400mg

About Sofohil tablets 400mg

Sofohil tablets 400mg Uses

• Treatment of chronic Hepatitis C infection in adults
• Used in combination with other antiviral medicines for higher cure rates
• Part of interferon free treatment regimens for Hepatitis C
• Prescribed for various Hepatitis C genotypes based on a doctor's assessment

Sofohil tablets 400mg Benefits

• High cure rates when combined with other direct acting antivirals
• Oral treatment avoids the need for interferon injections
• Shorter treatment courses compared to older Hepatitis C therapies
• Widely used and affordable generic option in Pakistan's Hepatitis C program

What Experts Say

Sofosbuvir is a direct acting antiviral that blocks an enzyme the Hepatitis C virus needs to copy itself, called NS5B polymerase. Stopping this enzyme prevents the virus from multiplying, which allows the body's own immune system to gradually clear the infection from the liver over the treatment course.

It is almost always combined with another antiviral medicine, such as daclatasvir or velpatasvir, rather than used alone, since combination therapy significantly improves cure rates. Treatment duration is usually twelve weeks, though some cases with liver cirrhosis may need a longer course.

Pakistan carries one of the highest Hepatitis C burdens in the world, and generic sofosbuvir combinations have made treatment far more accessible and affordable. Regular blood tests during and after treatment help confirm that the virus has been cleared successfully and the liver is recovering.

Drug Class

• Direct acting antiviral
• NS5B polymerase inhibitor
• Hepatitis C treatment medicine

Sofohil tablets 400mg formula

• Sofosbuvir 400mg

Available forms

• Tablet

How to use Sofohil tablets 400mg?

• Take one tablet daily, at the same time each day
• Take it with or without food as advised by your doctor
• Take it together with the second antiviral medicine your doctor prescribes
• Complete the full course even if you start feeling better
• Do not stop or skip doses without talking to your doctor

Drug Interactions

• Amiodarone: Combining can rarely cause a severe slow heartbeat.
• Rifampin: Reduces sofosbuvir levels and can lower its effectiveness.
• St John's Wort: This herbal supplement can reduce sofosbuvir levels in the blood.
• Certain Seizure Medicines: Drugs like carbamazepine can lower sofosbuvir effectiveness.

Risks and warnings

• Hepatitis B Reactivation: Can reactivate hidden Hepatitis B infection in some patients.
• Kidney Function: Dose adjustment or caution needed in significant kidney impairment.
• Pregnancy: Safety in pregnancy is not well established, discuss with your doctor.
• Heart Rhythm: Combining with amiodarone can rarely cause a dangerously slow heartbeat.
• Missed Doses: Skipping doses can reduce the chance of curing the infection.

Sofohil tablets 400mg Side Effects

• Fatigue
• Headache
• Nausea
• Insomnia
• Diarrhea
• Itching
• Low red blood cell count when combined with certain other antivirals
• Irritability

Storage Conditions

• Store below 30 degrees Celsius in a dry place
• Keep the tablets in their original packaging
• Protect from moisture and direct heat
• Keep out of reach of children