Tienam tablet 500mg

About Tienam tablet 500mg

Tienam 500mg Uses

• Severe hospital acquired infections
• Complicated intra abdominal infections
• Complicated urinary tract infections
• Pneumonia acquired in hospital settings
• Serious infections in patients with weakened immunity

Drug Class

• Carbapenem antibiotic
• Broad spectrum injectable antibiotic

What Experts Say

Imipenem kills bacteria by stopping them from building their protective cell wall, while cilastatin protects imipenem from breaking down in the kidneys.

Together they cover a very wide range of bacteria, which is why this combination is reserved for serious infections in a hospital setting.

It is given only as an injection into a vein or muscle, and it carries a higher seizure risk than many other antibiotics, especially in patients with kidney problems.

Tienam tablet 500mg formula

• Imipenem 500mg
• Cilastatin 500mg

Available forms

• Injection (IV/IM vial)

How to use Tienam tablet 500mg?

• Given only in a hospital or clinic by a doctor or nurse.
• Administered as an injection into a vein or muscle, never taken by mouth.
• The dose and frequency depend on kidney function and infection severity.
• Complete the full course as directed, even if symptoms improve early.

Drug Interactions

Tienam is given in a hospital setting where interactions are closely monitored.

• Valproic acid: Significantly lowers valproate levels and can trigger seizures.
• Ganciclovir: Increases the risk of seizures when combined.
• Probenecid: Can raise imipenem levels in the blood.

Risks and warnings

• Seizures: Higher risk in patients with kidney problems or existing seizure disorders.
• Penicillin allergy: Use with caution due to possible cross reaction.
• Kidney function: Dose must be adjusted based on kidney health.
• Severe diarrhea: Can cause serious intestinal infection with prolonged use.

Tienam 500mg Side Effects

• Nausea and vomiting
• Diarrhea
• Injection site pain or redness
• Skin rash
• Raised liver enzymes
• Seizures (uncommon, higher risk in kidney disease)

Storage Conditions

Store below 25°C, protect from light, and use immediately after reconstitution as directed by hospital staff.