Ultragesic tablet 37.5 / 325mg

About Ultragesic tablet 37.5 / 325mg

Ultragesic Uses

• Moderate to severe acute pain
• Post-operative pain
• Pain after dental procedures
• Musculoskeletal pain such as back pain
• Pain from fractures and sprains
• Cancer related pain when advised by a doctor

Ultragesic Benefits

• Provides faster relief than paracetamol alone
• Combines two pain pathways for a stronger effect
• Reduces the total opioid dose needed
• Convenient two in one tablet instead of separate pills

What Experts Say

Tramadol works on the central nervous system. It binds to opioid receptors and also affects serotonin and norepinephrine signaling. Paracetamol acts through a different pathway inside the brain. Together the two ingredients target pain from more than one direction, which is why doctors often prefer this fixed dose combination over a single painkiller alone.

In Pakistan, orthopedic and general physicians commonly prescribe Ultragesic after minor surgery, fractures, or dental work when plain paracetamol has not controlled the pain. It is meant for short courses of a few days rather than continuous long term use, since tramadol carries a real risk of tolerance and dependence with extended intake.

Doctors usually ask patients to avoid alcohol and other sedating medicines while taking this tablet, since the combination can cause drowsiness and slow breathing. People with a history of seizures, liver disease, or kidney impairment need dose adjustment and closer monitoring before starting therapy.

Drug Class

• Opioid analgesic combination
• Centrally acting analgesic

Ultragesic tablet 37.5 / 325mg formula

• Tramadol Hydrochloride
• Paracetamol

Available forms

• Tablet

How to use Ultragesic tablet 37.5 / 325mg?

• Take one tablet by mouth as directed by your doctor, usually every 4 to 6 hours when needed for pain.
• Do not take more than 8 tablets in 24 hours unless your doctor tells you otherwise.
• Swallow the tablet whole with a glass of water, with or without food.
• Do not crush, chew, or break the tablet since this can release the tramadol too quickly.
• Stop the tablet and inform your doctor once your pain is controlled, rather than continuing it as a routine medicine.

Drug Interactions

• Other opioids or sedatives: Combining with sleeping pills, benzodiazepines, or other opioids increases the risk of severe drowsiness and breathing difficulty.
• SSRIs and SNRIs: Taking tramadol with certain antidepressants can raise the risk of serotonin syndrome, a serious reaction.
• Alcohol: Drinking alcohol while on this tablet increases sedation and the risk of dangerously slow breathing.
• Other paracetamol containing medicines: Using additional cold, flu, or pain products with paracetamol can push the total daily dose above the safe limit.

Risks and warnings

• Dependence and misuse: Tramadol is an opioid and can lead to tolerance or dependence if used for long periods or in higher than prescribed doses.
• Breathing problems: High doses or combining with alcohol and sedatives can slow or stop breathing, especially in older adults.
• Seizure risk: Tramadol lowers the seizure threshold and should be used cautiously in people with epilepsy or a history of fits.
• Liver toxicity: The paracetamol component can damage the liver if taken above the recommended dose or with other paracetamol containing products.
• Not for children: This combination is not recommended for children under 12 years of age.

Ultragesic Side Effects

• Nausea and vomiting
• Dizziness or drowsiness
• Constipation
• Dry mouth
• Sweating
• Headache
• Low blood pressure on standing up

Storage Conditions

• Store at room temperature, away from direct heat and sunlight.
• Keep the tablets in their original blister pack until ready to use.
• Keep out of reach of children.