Urso Capsule 250mg

About Urso Capsule 250mg

Urso Capsule 250mg Uses

• Dissolving small cholesterol gallstones in patients who are not fit for surgery
• Primary biliary cholangitis, a chronic disease of the small bile ducts
• Cholestatic liver conditions where bile flow from the liver is reduced
• Preventing gallstone formation during rapid weight loss
• Improving raised liver enzymes caused by bile acid injury
• Supportive therapy in selected chronic liver diseases as advised by a specialist

Urso Capsule 250mg Benefits

• Dissolves suitable cholesterol gallstones without surgery
• Slows the progression of primary biliary cholangitis
• Protects liver cells from toxic bile acid damage
• Improves liver function test results with regular use
• Generally well tolerated during long term treatment
• Reduces the need for gallbladder removal in selected patients

What Experts Say

Hepatologists describe ursodeoxycholic acid as the first line therapy for primary biliary cholangitis. It is a hydrophilic bile acid that gradually replaces toxic, water repelling bile acids in the bile pool. This shift protects liver cells and small bile ducts from ongoing injury. With long term use, most patients show improved liver enzyme levels and slower disease progression.

Gastroenterologists in Pakistan also use it to dissolve small cholesterol gallstones in patients who are unfit for surgery or wish to avoid it. The medicine lowers cholesterol secretion into bile and slowly desaturates it, allowing stones to shrink. Complete dissolution may take 6 to 24 months, and stones must be radiolucent with a functioning gallbladder.

Specialists stress strict adherence because benefits build slowly and stones can return after stopping therapy. Liver function tests are checked every few months during treatment. Experts also note that calcified and pigment stones do not respond, so ultrasound based patient selection remains essential before starting.

Drug Class

• Bile Acid Agent

Urso Capsule 250mg formula

• Ursodeoxycholic Acid 250mg

Available forms

• Capsule

How to use Urso Capsule 250mg?

• Take Urso Capsule 250mg exactly as prescribed by your doctor
• Swallow the capsule whole with a glass of water
• Take it with food or milk to improve absorption
• Doses for gallstones are based on body weight and are often divided through the day
• Continue treatment for the full duration, since gallstone dissolution may take many months
• Attend regular follow up visits for liver tests and ultrasound checks
• If you miss a dose, take it when you remember unless the next dose is near

Drug Interactions

• Bile acid sequestrants (cholestyramine, colestipol): Bind the medicine in the gut and block its absorption, so doses should be separated by several hours.
• Aluminium containing antacids: Reduce absorption of ursodeoxycholic acid and should be taken at least 2 hours apart.
• Estrogens and oral contraceptives: Increase cholesterol in bile and can work against gallstone dissolution.
• Fibrate lipid medicines (clofibrate): Raise biliary cholesterol and may reduce the treatment effect.
• Ciclosporin: Its blood levels may rise, so doctors may adjust the dose and monitor closely.

Risks and warnings

• Prescription medicine: Use only under the supervision of a doctor.
• Liver monitoring: Your doctor will check liver function tests regularly during treatment.
• Not for all stones: It cannot dissolve calcified or pigment gallstones and needs a working gallbladder.
• Biliary obstruction: Do not use if the bile duct is fully blocked or during acute gallbladder inflammation.
• Warning signs: Seek urgent care for severe abdominal pain, fever, or yellowing of the skin or eyes.
• Pregnancy and breastfeeding: Use only if your doctor decides the benefit outweighs the risk.
• Allergy: Avoid if you have reacted to ursodeoxycholic acid or other bile acids before.

Urso Capsule 250mg Side Effects

• Diarrhea
• Pasty or loose stools
• Nausea
• Vomiting
• Indigestion or gas
• Abdominal pain
• Constipation
• Itching or mild skin rash
• Hair thinning
• Dizziness or headache

Storage Conditions

• Store below 30°C in a cool, dry place
• Keep the capsules in their original blister pack until use
• Protect from direct sunlight, heat, and moisture
• Keep out of the reach and sight of children
• Do not use capsules after the expiry date printed on the pack