Gravinate Tablet 50mg

About Gravinate Tablet 50mg

Gravinate Tablet Uses

• Prevention and treatment of motion sickness
• Relief of nausea and vomiting from travel by car, air, or sea
• Management of vertigo and vestibular disorders
• Treatment of dizziness caused by inner ear problems
• Relief of nausea and vomiting associated with Meniere's disease
• Control of postoperative nausea and vomiting in some cases
• Management of nausea caused by certain medications

Gravinate Tablet Benefits

• Acts on both the vomiting center in the brain and the inner ear, providing dual-action relief
• Effective for preventing motion sickness when taken before travel
• Provides relief from dizziness and loss of balance in vestibular disorders
• Available over the counter, making it accessible without a prescription for most patients
• Fast onset of action, with effects typically felt within 15 to 30 minutes

What Experts Say

Gravinate contains Dimenhydrinate, a combination of diphenhydramine and 8-chlorotheophylline. It belongs to the ethanolamine class of antihistamines and works by blocking H1 histamine receptors in the brain and inner ear. By suppressing stimulation of the vomiting center and reducing sensitivity of the vestibular apparatus, it effectively controls nausea, vomiting, and dizziness.

Dimenhydrinate is well established in clinical practice for motion sickness prophylaxis. When taken 30 minutes before travel, it significantly reduces the likelihood of nausea and vomiting during the journey. Its central nervous system depressant effect also contributes to its antiemetic action, though this same property is responsible for its sedating side effect.

Clinicians also use Dimenhydrinate for vestibular conditions such as Meniere's disease and labyrinthitis, where inner ear disturbance causes persistent dizziness and nausea. It is one of the more commonly available antiemetics in Pakistan and is frequently used in both outpatient and emergency care settings.

Drug Class

• Antihistamine
• Antiemetic

Packaging and Quantity

• 1 pack contains 10 strips
• 1 strip contains 10 tablets
• 100 tablets per pack

When Not to Use Gravinate

• Known allergy to Dimenhydrinate, diphenhydramine, or any ingredient in the tablet
• Children under 2 years of age
• Patients with acute asthma attacks or severe respiratory conditions
• Patients with angle-closure glaucoma
• Patients with urinary retention or bladder obstruction
• Epilepsy or seizure disorders, unless specifically advised by a doctor

Gravinate Tablet 50mg formula

• Dimenhydrinate

Available forms

• Tablet

How to use Gravinate Tablet 50mg?

• Gravinate tablet may be taken with or without food.
• The tablet should be swallowed whole with a full glass of water.
• For motion sickness, the tablet should be taken 30 minutes to 1 hour before travel begins.
• The prescribed dose must not be exceeded. Maximum 400mg per day for adults.
• Alcohol must be avoided during treatment as it significantly increases drowsiness.
• Driving or operating machinery should be avoided until the effect of the medicine on alertness is known.
• A doctor should be consulted if nausea or vomiting does not improve within 2 days.

Drug Interactions

Patients should inform their doctor about all medicines they are currently taking before starting Gravinate. Key interactions include:

• Alcohol: increases sedation and central nervous system depression. Avoid during treatment
• Other antihistamines: combining with additional antihistamines raises the risk of excessive sedation and anticholinergic effects
• Sedatives, sleeping tablets, and benzodiazepines: concurrent use significantly increases drowsiness and impairs coordination
• MAO inhibitors such as phenelzine and tranylcypromine: may intensify and prolong the anticholinergic effects of Dimenhydrinate
• Aminoglycoside antibiotics such as gentamicin: Dimenhydrinate may mask signs of ototoxicity caused by these drugs
• Anticholinergic medicines: additive effects may increase the risk of dry mouth, urinary retention, and constipation

Risks and warnings

• Sedation: Gravinate causes significant drowsiness. Patients must not drive or operate machinery until they know how the medicine affects them.
• Children: Dimenhydrinate can cause paradoxical excitability or restlessness in some children. Use with caution in pediatric patients.
• Elderly patients: Older adults are more sensitive to anticholinergic effects including confusion, urinary retention, and falls. Use the lowest effective dose.
• Glaucoma: Gravinate may worsen angle-closure glaucoma. Patients with this condition must not use it without specialist advice.
• Enlarged prostate: Anticholinergic effects can worsen urinary retention in patients with benign prostatic hyperplasia.
• Asthma and respiratory conditions: Use with caution in patients with chronic respiratory disease as Dimenhydrinate may thicken bronchial secretions.
• Pregnancy: Gravinate is not recommended during pregnancy unless specifically advised by a doctor. All risks and benefits must be discussed first.
• Breastfeeding: Dimenhydrinate passes into breast milk and may cause drowsiness in the infant. A doctor must be consulted before use.
• Liver disease: Use with caution in patients with hepatic impairment, as metabolism of the drug may be affected.

Gravinate Tablet Side Effects

Most patients tolerate Gravinate well at recommended doses. Side effects are generally mild and often improve as the body adjusts to the medicine.

• Drowsiness or sedation is the most common side effect
• Dry mouth
• Dizziness or headache
• Blurred vision
• Constipation
• Difficulty urinating
• Decreased coordination
• Restlessness or excitability, particularly in children

Serious side effects are uncommon. Medical attention should be sought immediately if any of the following occur:

• Fast or irregular heartbeat
• Difficulty breathing or chest tightness
• Severe confusion or hallucinations
• Seizures
• Severe allergic reaction including facial swelling, hives, or difficulty breathing

Storage Conditions

• Store at room temperature, below 25°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original packaging to protect from humidity.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the packaging.