Inderal (Propranolol) is a beta-blocker, a class of drugs that works by altering the functioning of your heart and blood vessels. So, the blood can circulate in your body with ease. Therefore, it is given mostly to control high blood pressure, often in combination with other drugs. Beta-blockers are given in many conditions related to the heart.
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What are the uses of Inderal?
Inderal can be given in conditions like:
- Hypertensive Retinopathy
- Renovascular Hypertension
- Hypertensive Encephalopathy
- Hypertensive Heart Disease
- Heart failure
- Heart attacks
- Kidney problems
- Kidney problems due to diabetes
- Myocardial Infarction
- Cardiovascular Disease
- Hypertensive Congestive Heart Failure
- Recent myocardial infarction
- Congestive Heart Failure
- Diabetic Nephropathy
- Hypertensive Heart (w/ CHF) and Renal Disease
- Hypertensive Renal Disease
- Atrial flutter
- Early intervention within 12 hours of myocardial ischemia
- Thyrotoxic crisis
- Prophylaxis of variceal bleeding in portal hypertension
- Phaeochromocytoma (only with an alpha-blocker) in preparation for surgery
- Anxiety with symptoms such as palpitation, sweating, and tremor
- Migraine prophylaxis
How to take Inderal?
You should take an Inderal tablet with a glass of water. Swallow it whole. Follow the dose and frequency as advised by the doctor. Do not alter the dose and frequency, as it can lead to other problems. Also, do not miss the dose on your own even if your blood pressure remains normal. Take the medication at the same time of the day, every day.
Before stopping its use, you must consult with a healthcare provider.
Moreover, do not stop taking beta-blockers suddenly on your own or if they cause any adverse effects. Doing that can negatively affect your health by increasing the chances of rebound tachycardia, heart attack, and arrhythmias. Your healthcare provider will systematically taper off the drug and provide another medication to relieve the condition.
Inderal dosage and strength
Inderal is available in tablet form having the strength of 10mg, 40mg, 80mg, and 160mg
The dosage of Inderal for patients according to the respective conditions is as follows:
Initially 40 mg twice daily, the dose should be increased at weekly intervals as required. The maintenance dosage is normally 120 mg to 240 mg per day.
Take 80 mg to 320 mg of Inderal, orally, twice a day.
80 mg Inderal should be taken daily in divided doses. The normal effective dose range is 160 mg to 240 mg daily. Inderal dosage may be slowly increased to reach optimum migraine prophylaxis.
However, if an adequate response is not achieved after reaching the maximum dose, after 4 to 6 weeks, you should discontinue However, it should be done gradually, spread over a period of several weeks.
IMPORTANT NOTE: Refer to your doctor before taking Inderal and never consume it more than the dosage or strength prescribed by the doctor.
What are the side effects of Inderal?
The side effects of Inderal are;
- Orthostatic hypotension
- Dry mouth
- Hemolytic anemia
- Diabetes mellitus
- Inappropriate antidiuretic hormone secretion
- Cutaneous pseudolymphoma
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- Visual loss
- Blurred vision
- Taste disturbances
- Olfactory disturbance
- Elevated erythrocyte sedimentation rate
- Hyperkalemia- a life-threatening condition in which potassium levels rise in your body. To avoid hyperkalemia, serum potassium levels should be kept under check.
The chemical composition of Inderal is Propranolol.
What are alternatives to Inderal?
You can find the alternatives for Propranolol by the following names;
What are the available forms of Inderal?
Inderal is available in tablet form and is taken orally.
What are the risks and warnings for Inderal?
If you are hypersensitive to Beta-blockers, do not take Inderal or any other medicine with a similar generic name, as it can result in a life-threatening condition called anaphylactic shock. Always inform your healthcare provider about the documented allergies you have.
You should take Inderal during pregnancy only if your health care provider prescribes it. They may decide it based on the risk versus benefit ratio. Otherwise, taking beta-blockers during pregnancy, especially during the second and third trimester, can be injurious to your baby’s health.
Mothers who are breastfeeding their child should take Inderal only on the advice of their healthcare provider as some of its concentration can be present in breast milk and affect your child’s health.
If you have a complaint of heart block, do not use Propranolol.
Bradycardia is a condition in which your heart rate remains slower than normal. If you have the same condition, do not take Propranolol as it can also slow down the heart rate, which can become life-threatening.
If you have diabetes, you must take a beta-blocker with extreme caution. Your pancreas contains beta receptors that produce insulin. Beta-blockers may alter the functioning of the pancreas to produce insulin. Therefore you need to exercise caution if you have diabetes already, as it can make it difficult to control blood sugar levels.
Conditions that lower blood pressure
If you are on medications like diuretics or having a health condition like diarrhea, volume depletion, heatstroke, or infections that lower blood pressure, take Inderal with caution, as it can lead to severely low blood pressure that can be life-threatening.
If you have heart diseases like ischemic heart disease or cerebrovascular disease in which blood pressure may fall below normal levels, you should be cautious while taking Inderal or any other Beta-blocker. Before taking any medicine that lowers blood pressure, it would be better if you check the blood pressure reading once.
In people with heart failure who have normal blood pressure, taking Inderal can cause a blood pressure drop. The low blood pressure in patients with heart failure taking Inderal can adversely affect renal function too. Therefore, you should be cautious while taking a beta-blocker if you have heart failure with normal blood pressure.
Aortic or mitral valve stenosis
If you have aortic or mitral valve stenosis or hypertrophic cardiomyopathy that obstructs the outflow of the left ventricle, beta-blockers should be taken with extreme caution.
Renal function impairment
Patients with renal impairment must be cautious while taking a beta-blocker. Your healthcare provider will test serum creatinine and potassium levels frequently if you take Inderal with compromised renal functions.
Patients with diabetic nephropathy taking beta-blockers should also be cautious about it.
Patients with liver disease should take Inderal with caution. It is because your liver helps in the metabolism and excretion of drugs. When it does not work efficiently due to any disease, it can cause accumulation of the drug in your body, leading to severe adverse effects. Very rarely, Inderal affects your liver function, causing cholestatic jaundice leading to fulminant jaundice. If it occurs, the healthcare providers will promptly stop the therapy.
Asthma and other respiratory conditions
Beta-blockers, especially Propranolol, should never be given to an asthmatic patient. It can cause constriction of the bronchioles that make it hard for you to breathe. Beta blocker-induced asthma may show up as wheezing, chest tightness, or cough. If you have any of these side effects, you should visit your doctor as soon as possible as it can become life-threatening.
People having other respiratory conditions like bronchitis, emphysema and allergies should also avoid its use.
People undergoing anesthesia may receive agents that lower blood pressure. Therefore beta-blockers should only be given if blood pressure needs to be controlled and there is no risk of hypotension. Otherwise, it can lead to a life-threatening condition called shock.
Beta-blockers cause hyperkalemia- means excess potassium in your blood that can become a life-threatening condition. People taking potassium supplements or having renal impairment, or eating a diet rich in potassium like dates and bananas are at higher risk of developing life-threatening hyperkalemia. To avoid it, you should get your serum potassium levels checked frequently and avoid eating potassium-rich foods.
Diabetic patients receiving oral hypoglycemics or insulin as treatment should take Inderal with caution, as they can cause hypoglycemia- a life-threatening condition in which blood sugar levels are lower than normal. Beta-blockers can mask the symptoms of hypoglycemia. Therefore, they should be only co-prescribed if the benefit is more than the risk.
Cardiac glycosides/calcium channel blockers and amiodarone
Taking Propranolol with digoxin, verapamil, and amiodarone can cause heart block, ventricular dysfunction, and bradycardia. Therefore, both drugs should not be combined or should be taken with extreme caution.
Anticoagulants or bleeding disorders
If you are taking anticoagulants for thinning of your blood, or you have any bleeding disorder, take Inderal only on the advice of a healthcare provider.
Take beta-blockers with caution if you have hyperthyroidism as they can mask its symptoms, without treating the underlying cause.
If you have pheochromocytoma, do not take beta-blockers alone as they can cause hypertensive crises or pulmonary edema.
Interactions between Inderal and other medications
Inderal is a beta-blocker. It may interact with the following drugs. A drug interaction does not mean that you stop taking the medicine on your own. But you must tell your healthcare provider about it.
- Potassium-sparing diuretics like spironolactone, triamterene, and eplerenone
- Antidiabetic medicines like metformin, pioglitazone, and others
- NSAIDs like ibuprofen, naproxen, indomethacin and others
- Vasodilators like nitroglycerin
- Corticosteroids like prednisolone
- Amphotericin B
- Statins like atrovastain, lovastatin, rosuvastatin and others
- Calcium channel blockers like verapamil
To avoid drug interactions, you must give a complete history to the healthcare provider about other health conditions you have and what medicines you have been taking. At times, a dose adjustment can help prevent drug interaction.
Inderal price in Pakistan in 2022
Inderal 10 mg price in Pakistan
The price of the Inderal 10mg tablet in Pakistan in the year 2022 is Rs. 1.82/tablet approximately.
- Keep the product out of the reach and sight of children.
- Store it at room temperature.
- Do not use it after the mentioned expiry date.
Do you need a prescription to buy Inderal?
For buying Inderal, you are required to have a prescription signed by your doctor.