Acefyl Syrup 125ml

About Acefyl Syrup 125ml

About Acefyl Syrup

Acefyl is a combination bronchodilator and antihistamine syrup by Nabiqasim Industries containing Acefylline Piperazine and Diphenhydramine, used to relieve wet cough, chest congestion, and allergy-related respiratory symptoms.

Acefyl Syrup Uses

• Productive (wet) cough associated with mucus accumulation in the airways.
• Chest congestion and bronchial mucus buildup caused by upper and lower respiratory tract infections.
• Allergic cough triggered by dust, pollen, or environmental allergens.
• Bronchial asthma with associated cough and mild airway constriction.
• Acute and chronic bronchitis with mucus production.
• Cough associated with the common cold, flu, or sinusitis.
• Nasal congestion and runny nose accompanying allergy-related cough.

Acefyl Syrup Benefits

• Combines a bronchodilator and an antihistamine in one syrup, addressing both airway constriction and allergic triggers simultaneously.
• Acefylline opens constricted airways, making breathing easier and allowing mucus to be cleared more effectively.
• Diphenhydramine suppresses the cough reflex and reduces allergy-driven irritation in the nasal passages and throat.
• Suitable for both adults and children, with age-appropriate doses making it a practical choice for household respiratory management.
• Provides dual-action relief without requiring two separate medicines, simplifying treatment for cough with an allergic component.

What Experts Say

Acefyl combines two active agents with distinct mechanisms, making it effective for cough that has both an obstructive airway component and an allergic trigger.

How It Works

Acefylline Piperazine is a methylxanthine derivative that inhibits phosphodiesterase enzymes, preventing the breakdown of cyclic adenosine monophosphate (cAMP) inside airway smooth muscle cells. Raised cAMP levels cause bronchial smooth muscle to relax, widening the airways and improving airflow. Acefylline also antagonizes adenosine receptors in the airways, blocking a secondary pathway that promotes bronchoconstriction and mucus secretion.

The Role of Diphenhydramine

Diphenhydramine Hydrochloride is a first-generation H1 receptor antagonist that blocks histamine at peripheral receptors in the respiratory mucosa and nasal passages. Unlike second-generation antihistamines, it crosses the blood-brain barrier, producing central sedation that suppresses the cough reflex and aids sleep in patients with persistent nighttime coughing. This CNS penetration is clinically useful but requires caution regarding driving and concurrent sedative use.

Clinical Note

Acefylline can cause palpitations and increased heart rate at higher doses due to its xanthine-class cardiac effects. Diphenhydramine's anticholinergic properties can cause urinary retention and raise intraocular pressure, making Acefyl unsuitable for patients with prostatic hypertrophy or narrow-angle glaucoma. Acefyl is not appropriate for dry or unproductive cough, where neither ingredient provides meaningful benefit.

Drug Class

• Combination Bronchodilator and Antihistamine.
• Acefylline Piperazine: Xanthine Derivative, Bronchodilator.
• Diphenhydramine Hydrochloride: First-Generation H1 Receptor Antagonist.

Packaging and Quantity

• Available in 60ml and 120ml syrup bottles.
• Each 5ml contains Acefylline Piperazine 45mg and Diphenhydramine HCl 8mg.
• A measuring cup or dosing spoon is included with each bottle.

When Not to Use Acefyl

• Known allergy or hypersensitivity to Acefylline, Diphenhydramine, or any antihistamine or xanthine derivative.
• Acute narrow-angle glaucoma, as Diphenhydramine's anticholinergic effect can raise intraocular pressure.
• Symptomatic benign prostatic hypertrophy or urinary retention, as anticholinergic effects may worsen urinary symptoms.
• Dry or unproductive cough where mucus is not the cause of coughing.
• Concurrent use of MAO inhibitors or within 14 days of stopping an MAO inhibitor.

Acefyl Syrup 125ml formula

• Acefylline + Diphenhydramine

Available forms

• Syrup

How to use Acefyl Syrup 125ml?

• Shake the bottle well before every dose to ensure even distribution of the active ingredients.
• Use the measuring cup provided to ensure accurate dosing. Do not estimate.
• Acefyl may be taken with or without food.
• Alcohol, sedatives, and sleep medicines must be avoided during treatment as they enhance the sedative effect of Diphenhydramine.
• The standard adult dose is 10ml (2 teaspoons) three to four times daily. Children's doses vary by age: infants take 1.25ml (quarter teaspoon) three times daily, children take 2.5ml (half teaspoon) three times daily.
• The dose should not be exceeded without consulting a doctor. If symptoms do not improve within 5 to 7 days, a doctor should be consulted.

Drug Interactions

Diphenhydramine in Acefyl has several clinically relevant interactions. All current medicines must be disclosed to the prescribing doctor before starting Acefyl. Key interactions include:

• Alcohol: significantly enhances CNS depression and sedation caused by Diphenhydramine. Must be strictly avoided during treatment.
• Other CNS depressants including sedatives, anxiolytics, opioids, and antipsychotics: additive sedation and respiratory depression can occur.
• MAO inhibitors: concurrent use with Diphenhydramine is contraindicated and can cause a hypertensive crisis or dangerous CNS effects.
• Tricyclic antidepressants: additive anticholinergic effects including urinary retention, dry mouth, and constipation.
• Other antihistamines: concurrent use doubles anticholinergic side effects without additional antiallergic benefit.
• Beta-blockers: Acefylline may reduce the effectiveness of beta-blockers and can cause mutual interference in cardiac effects.

Risks and warnings

• Pregnancy: The safety of Acefyl during pregnancy has not been established. It should only be used during pregnancy under direct medical supervision when the benefit clearly outweighs the risk.
• Breastfeeding: Diphenhydramine passes into breast milk and can cause sedation in the infant. Breastfeeding is not recommended during treatment with Acefyl.
• Cardiovascular disease: Acefylline can cause palpitations and increased heart rate. Patients with heart disease, arrhythmias, or hypertension should use Acefyl with caution and under medical supervision.
• Glaucoma: Diphenhydramine's anticholinergic effect can raise intraocular pressure and is contraindicated in patients with narrow-angle glaucoma.
• Prostatic hypertrophy: Anticholinergic effects of Diphenhydramine may cause or worsen urinary retention in men with an enlarged prostate.
• Liver and kidney disease: Patients with significant liver or kidney impairment should use Acefyl with caution, as both active ingredients require hepatic and renal processing.
• Elderly patients: Older adults are more sensitive to the sedative and anticholinergic effects of Diphenhydramine, raising the risk of falls, confusion, and urinary retention.
• Driving and machinery: Acefyl causes significant drowsiness due to Diphenhydramine. Driving and operating heavy machinery must be avoided during treatment.
• Children under 2 years: Acefyl should not be used in infants under 2 years without explicit medical supervision.

Acefyl Syrup Side Effects

Most patients tolerate Acefyl well at recommended doses. Side effects are generally mild and more common when the dose is exceeded.

• Drowsiness or sedation caused by Diphenhydramine, particularly in the first few days of use.
• Dry mouth, nose, or throat due to the anticholinergic effect of Diphenhydramine.
• Nausea or mild stomach discomfort.
• Dizziness or lightheadedness.
• Palpitations or increased heart rate caused by Acefylline at higher doses.
• Headache or restlessness.
• Urinary hesitancy or difficulty urinating, particularly in older male patients.

Serious side effects are rare. Medical attention should be sought immediately if any of the following occur:

• Severe allergic reaction including facial swelling, difficulty breathing, or widespread rash.
• Rapid or irregular heartbeat that is persistent or distressing.
• Difficulty urinating or complete inability to urinate.
• Confusion or agitation, particularly in elderly patients.
• Worsening breathing or chest tightness after taking Acefyl.

Storage Conditions

• Store at room temperature, between 15°C and 30°C.
• Keep away from direct sunlight, heat, and moisture.
• Always keep the bottle tightly capped after use.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the bottle.
• Do not store in the bathroom or near a kitchen sink.