Airtal Tablet 100mg

About Airtal Tablet 100mg

Airtal Tablet Uses

• Rheumatoid arthritis, including joint pain, swelling, and morning stiffness.
• Osteoarthritis, including pain and reduced mobility in the knees, hips, and hands.
• Ankylosing spondylitis affecting the spine and sacroiliac joints.
• Cervicalgia (neck pain) caused by cervical spondylosis or muscle tension.
• Lumbago and lumbosciatica (lower back pain radiating to the leg).
• Tendinitis and soft tissue inflammation including sprains and strains.
• Scapulohumeral periarthritis (shoulder pain and stiffness).
• Myalgia (muscle pain) of various causes.
• Primary dysmenorrhea (menstrual cramps).
• Post-labour and post-episiotomy pain.
• Toothache and dental pain (odontalgia).

Airtal Tablet Benefits

• Provides effective relief from both acute and chronic inflammatory pain with a twice-daily dosing schedule.
• Produces less gastrointestinal irritation than older NSAIDs such as Diclofenac and Ibuprofen, making it better tolerated in patients with sensitive stomachs.
• Shown in clinical studies to stimulate cartilage matrix synthesis, which may offer a degree of protection to joint tissue beyond simple pain relief.
• Acts on both COX enzymes and the lipooxygenase pathway, providing broader anti-inflammatory coverage than selective COX-2 inhibitors alone.
• Effective across a wide range of pain conditions from arthritis to post-operative and gynaecological pain, reducing the need for multiple analgesics.

What Experts Say

Airtal contains Aceclofenac, a phenylacetic acid derivative NSAID that inhibits both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. These enzymes catalyze the conversion of arachidonic acid into prostaglandins, the primary chemical mediators of pain, swelling, and fever at sites of tissue injury. By blocking prostaglandin synthesis, Aceclofenac reduces peripheral sensitization of pain receptors and decreases the inflammatory response in affected joints and soft tissues.

What distinguishes Aceclofenac from older NSAIDs such as Diclofenac is its dual metabolic profile. A significant proportion of Aceclofenac is converted in the body to 4-hydroxy Aceclofenac and, to a lesser extent, to Diclofenac itself. This metabolite activity partially explains Aceclofenac's clinical effectiveness. Importantly, Aceclofenac has been shown in vitro to stimulate the synthesis of interleukin-1 receptor antagonist (IL-1Ra), which inhibits the destructive effects of IL-1 on cartilage. This cartilage-protective effect, while not yet fully established in large clinical trials, distinguishes Aceclofenac from standard NSAIDs and has made it a preferred choice among rheumatologists for long-term arthritis management.

Aceclofenac has a preferential but not selective inhibitory effect on COX-2, which contributes to its relatively better gastrointestinal tolerability compared to non-selective NSAIDs. However, it is not a COX-2 selective inhibitor and carries the same class-wide cardiovascular and renal warnings as other NSAIDs. Clinicians should assess the cardiovascular risk profile before initiating long-term Aceclofenac therapy and prescribe the lowest effective dose for the shortest necessary duration.

Drug Class

• Non-Steroidal Anti-Inflammatory Drug (NSAID).
• Phenylacetic Acid Derivative.

Packaging and Quantity

• 1 pack contains 20 tablets.
• Packaged as 2 strips of 10 tablets each.

When Not to Use Airtal

• Known allergy or hypersensitivity to Aceclofenac, Aspirin, or any other NSAID.
• History of asthma, urticaria, or allergic reactions triggered by Aspirin or other NSAIDs.
• Active stomach or duodenal ulcers, or a history of gastrointestinal bleeding.
• Severe liver, kidney, or heart failure.
• Third trimester of pregnancy.
• Recent or upcoming heart bypass (CABG) surgery.

Airtal Tablet 100mg formula

• Aceclofenac

Available forms

• Tablets

How to use Airtal Tablet 100mg?

• Airtal may be taken with or after food to reduce the risk of stomach upset.
• The tablet should be swallowed whole with a full glass of water.
• This medicine should be used for the shortest time necessary to control symptoms.
• If stomach pain, black stools, or nausea occurs, a doctor should be informed immediately.
• The standard adult dose is 100mg twice daily, once in the morning and once in the evening.
• The dose should not be increased or the duration extended without consulting a doctor.

Drug Interactions

Airtal Tablet can interact with the following drugs:

• Other Non-steroidal anti-inflammatory drugs (NSAIDs)
• Blood thinners
• Alcohol

Risks and warnings

• Pregnancy: Airtal is contraindicated in the third trimester and should be used with extreme caution in the first and second trimesters only under direct medical supervision.
• Breastfeeding: the safety of Aceclofenac during breastfeeding has not been established. A doctor should be consulted before use.
• Cardiovascular risk: like all NSAIDs, Airtal carries a risk of serious cardiovascular events including heart attack and stroke. The risk is higher with long-term use and in patients with existing heart disease.
• Gastrointestinal risk: Airtal can cause gastrointestinal ulcers and bleeding, which can be fatal. The risk is higher in elderly patients and those with a history of ulcers.
• Kidney disease: long-term use can impair kidney function. Patients with existing kidney disease should use the lowest effective dose under close monitoring.
• Liver disease: Aceclofenac is metabolized by the liver. Patients with liver impairment should use Airtal with caution and have liver enzymes monitored.
• Asthma: Airtal may trigger or worsen asthma attacks, particularly in patients with aspirin-sensitive asthma. It should be discontinued immediately if breathing worsens.
• Elderly patients: the risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events is significantly higher in patients above 65. The lowest effective dose should always be used.
• Driving and machinery: Airtal may cause dizziness. Caution is advised when driving or operating heavy machinery until the individual response is known.

Airtal Tablet Side Effects

Most patients tolerate Airtal well at the recommended dose. Side effects are generally mild and improve after the first few days of treatment.

• Nausea or mild stomach discomfort.
• Diarrhea or loose stools.
• Dizziness or headache.
• Mouth ulcers (aphthous stomatitis).
• Skin rash or itching.
• Mild ankle swelling due to fluid retention.
• Elevated liver enzymes on blood tests, usually without symptoms.

Serious side effects are rare. Medical attention should be sought immediately if any of the following occur:

• Black or tarry stools, vomiting blood, or severe abdominal pain, which may indicate gastrointestinal bleeding.
• Chest pain, shortness of breath, or sudden weakness on one side of the body, which may indicate a cardiovascular event.
• Significantly reduced urination or unusual swelling, which may indicate kidney damage.
• Yellowing of the skin or eyes, which may indicate liver damage.
• Severe allergic reaction including facial swelling, difficulty breathing, or widespread rash.
• Worsening of asthma symptoms after taking Airtal.

Storage Conditions

• Store at room temperature, below 25°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original packaging to protect from humidity.
• Keep out of reach and sight of children.
• Do not use after the expiry date printed on the packaging.
• Do not store in the bathroom or near a kitchen sink.