Angised Tablet 0.5mg

About Angised Tablet 0.5mg

Angised Tablet Uses

• Rapid relief of acute angina pectoris and chest pain caused by coronary artery disease.
• Prevention of angina attacks when taken before activities known to trigger symptoms.
• Emergency treatment of chest pain during acute myocardial infarction.
• Control of hypertension during cardiac surgery and perioperative cardiac events.

Angised Tablet Benefits

• Fast-acting sublingual formulation provides relief within 1 to 3 minutes.
• Dilates coronary blood vessels and increases oxygen supply to heart muscle.
• Reduces preload and afterload on the heart, decreasing cardiac workload.
• Improves blood flow throughout the body by promoting vasodilation.
• Portable and convenient for on-demand symptom relief.

What Experts Say

Glyceryl trinitrate is a potent organic nitrate that releases nitric oxide in vascular smooth muscle cells. Nitric oxide activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) levels, which promotes smooth muscle relaxation and vasodilation. This mechanism preferentially dilates peripheral veins and coronary arteries, reducing cardiac preload and improving coronary blood flow.

Sublingual administration bypasses first-pass hepatic metabolism, allowing rapid absorption through the oral mucosa. Peak plasma concentrations are achieved within 1 to 3 minutes, corresponding with symptom relief. The drug undergoes rapid hepatic metabolism with a half-life of 1 to 4 minutes, requiring frequent dosing for sustained effect or the use of extended-release formulations.

Tolerance to nitrate effects develops with continuous exposure, making intermittent dosing and nitrate-free intervals essential for maintaining efficacy. The sublingual tablet formulation provides the fastest onset among nitrate preparations, making it ideal for acute angina relief.

Drug Class

• Nitrate Vasodilator

Packaging and Quantity

• Blister pack or bottle containing 60 tablets.

When Not to Use Angised

• Known allergy to glyceryl trinitrate or any component.
• Concurrent use with phosphodiesterase-5 inhibitors including sildenafil or tadalafil.
• Severe hypotension or shock without medical supervision.
• Recent head injury or increased intracranial pressure.

Angised Tablet 0.5mg formula

• Glyceryl Trinitrate

Available forms

• Tablets

How to use Angised Tablet 0.5mg?

• Place one tablet under the tongue at the first sign of angina.
• Allow the tablet to dissolve completely without chewing or swallowing.
• Sit or rest while waiting for the medication to take effect.
• If chest pain continues after 5 minutes, a second tablet may be taken.
• If pain persists after a second dose, seek emergency medical attention immediately.
• Place one 0.5mg tablet under the tongue as needed for angina relief.

Drug Interactions

Glyceryl trinitrate may interact with several medications affecting safety and efficacy:

• Phosphodiesterase-5 inhibitors: Absolute contraindication with sildenafil, tadalafil, or vardenafil due to severe hypotension risk.
• Riociguat: Contraindicated due to risk of severe hypotension and syncope.
• Antihypertensive medications: Combined use may cause excessive blood pressure reduction.
• Tricyclic antidepressants: May increase anticholinergic effects and worsen hypotension.
• Alcohol: Significantly enhances hypotensive effects and dizziness.

Risks and warnings

• PDE5 inhibitors: Absolute contraindication; life-threatening hypotension may occur.
• Hypotension risk: Monitor blood pressure; may cause fainting, especially on initial dosing.
• Nitrate tolerance: Tolerance develops with continuous use; maintain nitrate-free intervals.
• Alcohol interaction: Avoid alcohol as it significantly enhances hypotensive effects.
• Headache management: Headaches are common but usually decrease over time.
• Emergency escalation: Seek emergency care if pain persists after two doses.
• Original packaging: Keep tablets in original container until just before use.

Angised Tablet Side Effects

Most patients tolerate Angised well. Common side effects are usually mild and transient.

• Headache or throbbing sensation.
• Dizziness or lightheadedness.
• Flushing or facial redness.
• Palpitations or rapid heartbeat.
• Weakness or fatigue.

Effects requiring medical attention are less common but include:

• Severe hypotension or syncope.
• Severe headache that does not respond to pain relief.
• Severe allergic reactions or angioedema.
• Methemoglobinemia with excessive dosing or prolonged use.

Storage Conditions

• Store at room temperature between 15°C and 30°C.
• Keep away from direct sunlight, heat, and moisture.
• Store in the original container with the lid tightly closed.
• Do not transfer tablets to other containers or pill boxes.
• Keep out of reach of children and pets.
• Do not use after the expiration date printed on the packaging.